Mettl2 methyltransferase like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mettl2provided by RGD
Official Full Name: methyltransferase like 2provided by RGD
Primary source: RGD:1310240
See related: EnsemblRapid:ENSRNOG00000006131 AllianceGenome:RGD:1310240
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mettl2b
Summary: Predicted to enable tRNA (cytidine-3-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be located in cytoplasm. Orthologous to several human genes including METTL2A (methyltransferase 2A, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 104.7), Thymus (RPKM 67.6) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q32.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (90595411..90609234)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (90095527..90109354)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (93353944..93367769)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables tRNA (cytidine-3-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA (cytidine-3-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in tRNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in tRNA methylation	ISO Inferred from Sequence Orthology more info
involved_in tRNA modification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: methyltransferase-like protein 2A

Names: methyltransferase like 2B

NP_001102309.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108839.1 → NP_001102309.1 methyltransferase-like protein 2A

See identical proteins and their annotated locations for NP_001102309.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A0A8I6GDZ5, A6HJX3, D3ZQ63

Related

ENSRNOP00000085553.1, ENSRNOT00000102988.2

Conserved Domains (2) summary

COG0500
Location:181 → 302

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

pfam08242
Location:183 → 285

Methyltransf_12; Methyltransferase domain