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    Fbxl7 F-box and leucine-rich repeat protein 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361907, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbxl7provided by RGD
    Official Full Name
    F-box and leucine-rich repeat protein 7provided by RGD
    Primary source
    RGD:1305813
    See related
    EnsemblRapid:ENSRNOG00000024433 AllianceGenome:RGD:1305813
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in G2/M transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to be located in centrosome. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL7 (F-box and leucine rich repeat protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 22.5), Heart (RPKM 17.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Fbxl7 in Genome Data Viewer
    Location:
    2q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (78870236..79239697, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (77139775..77509223, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (79067907..79439987, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485864 Neighboring gene membrane associated ring-CH-type finger 11 Neighboring gene uncharacterized LOC120100752 Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 10 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex  
    part_of SCF ubiquitin ligase complex  
    located_in centrosome  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108545.1NP_001102015.1  F-box/LRR-repeat protein 7

      See identical proteins and their annotated locations for NP_001102015.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473992
      UniProtKB/TrEMBL
      A6JMX5, F1M6W6
      Related
      ENSRNOP00000033571.7, ENSRNOT00000031170.8
      Conserved Domains (3) summary
      cd09293
      Location:297464
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:240273
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:114160
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      78870236..79239697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102576.1XP_038958504.1  F-box/LRR-repeat protein 7 isoform X1

      Conserved Domains (3) summary
      cd09293
      Location:250417
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:193226
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:67110
      F-box-like
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