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    Ankrd11 ankyrin repeat domain containing 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365023, updated on 27-Dec-2024

    Summary

    Official Symbol
    Ankrd11provided by RGD
    Official Full Name
    ankyrin repeat domain containing 11provided by RGD
    Primary source
    RGD:1306679
    See related
    EnsemblRapid:ENSRNOG00000027906 AllianceGenome:RGD:1306679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein homodimerization activity. Predicted to be involved in anatomical structure morphogenesis. Predicted to act upstream of or within several processes, including face morphogenesis; skeletal system development; and social behavior. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromatin. Human ortholog(s) of this gene implicated in KBG syndrome. Orthologous to human ANKRD11 (ankyrin repeat domain containing 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 150.0), Adrenal (RPKM 148.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ankrd11 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (67848836..68007491, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (50940284..51098962, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (55703831..55862446, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348960 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene acyl-CoA synthetase family member 3 Neighboring gene cadherin 15 Neighboring gene small nucleolar RNA U3 Neighboring gene ribosomal protein S13, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis  
    involved_in biological_process  
    acts_upstream_of_or_within bone development  
    acts_upstream_of_or_within cognition  
    acts_upstream_of_or_within face development  
    acts_upstream_of_or_within face morphogenesis  
    acts_upstream_of_or_within gene expression  
    acts_upstream_of_or_within head development  
    acts_upstream_of_or_within head morphogenesis  
    acts_upstream_of_or_within in utero embryonic development  
    acts_upstream_of_or_within localization of cell  
    acts_upstream_of_or_within multicellular organism growth  
    acts_upstream_of_or_within neural precursor cell proliferation  
    acts_upstream_of_or_within neurogenesis  
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth  
    acts_upstream_of_or_within ossification  
    acts_upstream_of_or_within proteasomal protein catabolic process  
    acts_upstream_of_or_within protein acetylation  
    acts_upstream_of_or_within protein catabolic process  
    acts_upstream_of_or_within roof of mouth development  
    acts_upstream_of_or_within skeletal system morphogenesis  
    acts_upstream_of_or_within social behavior  
    acts_upstream_of_or_within tissue homeostasis  
    Component Evidence Code Pubs
    is_active_in chromatin  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    ankyrin repeat domain-containing protein 11
    Names
    ankyrin repeat domain 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374009.1NP_001360938.1  ankyrin repeat domain-containing protein 11

      Status: VALIDATED

      Source sequence(s)
      CA504097, JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6AA00, A0A8I6G4N3
      Related
      ENSRNOP00000090403.1, ENSRNOT00000113041.2
      Conserved Domains (4) summary
      PTZ00121
      Location:7321634
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:18582369
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:167198
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:172264
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      67848836..68007491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772667.4XP_008770889.1  ankyrin repeat domain-containing protein 11 isoform X1

      See identical proteins and their annotated locations for XP_008770889.1

      UniProtKB/TrEMBL
      A0A8I6G4N3
      Conserved Domains (4) summary
      cd00204
      Location:161283
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:171263
      Ank_2; Ankyrin repeats (3 copies)
      pfam15822
      Location:18192029
      MISS; MAPK-interacting and spindle-stabilizing protein-like
      sd00045
      Location:166197
      ANK; ANK repeat [structural motif]
    2. XM_063278178.1XP_063134248.1  ankyrin repeat domain-containing protein 11 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZRF5, D3ZSU6
      Related
      ENSRNOP00000035742.6, ENSRNOT00000031389.9
    3. XM_039097915.2XP_038953843.1  ankyrin repeat domain-containing protein 11 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G4N3
      Conserved Domains (4) summary
      PTZ00121
      Location:5721474
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:16982209
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:4171
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:45127
      Ank_2; Ankyrin repeats (3 copies)
    4. XM_039097914.2XP_038953842.1  ankyrin repeat domain-containing protein 11 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G4N3
      Conserved Domains (4) summary
      PTZ00121
      Location:5721474
      PTZ00121; MAEBL; Provisional
      PHA03247
      Location:16982209
      PHA03247; large tegument protein UL36; Provisional
      sd00045
      Location:4171
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:45127
      Ank_2; Ankyrin repeats (3 copies)

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