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    Piwil2 piwi-like RNA-mediated gene silencing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306011, updated on 9-Dec-2024

    Summary

    Official Symbol
    Piwil2provided by RGD
    Official Full Name
    piwi-like RNA-mediated gene silencing 2provided by RGD
    Primary source
    RGD:1306964
    See related
    EnsemblRapid:ENSRNOG00000009871 AllianceGenome:RGD:1306964
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA endonuclease activity; mRNA binding activity; and piRNA binding activity. Predicted to be involved in several processes, including germ-line stem cell population maintenance; negative regulation of circadian rhythm; and regulation of gene expression. Predicted to act upstream of with a positive effect on piRNA-mediated retrotransposon silencing by heterochromatin formation. Predicted to act upstream of or within positive regulation of meiosis I. Predicted to be located in cytoplasmic ribonucleoprotein granule; dense body; and perinucleolar chromocenter. Predicted to be part of PET complex. Predicted to be active in P granule and nucleus. Orthologous to human PIWIL2 (piwi like RNA-mediated gene silencing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 130.6), Heart (RPKM 65.6) and 1 other tissue See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Piwil2 in Genome Data Viewer
    Location:
    15p11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (51841104..51907729, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45431402..45498034, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (52037693..52116277, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 3 catalytic subunit gamma Neighboring gene mitochondrial pyruvate carrier 1-like Neighboring gene solute carrier family 39 member 14 Neighboring gene histone deacetylase 1-like Neighboring gene small nucleolar RNA SNORA70 Neighboring gene transfer RNA proline (anticodon AGG) 23 Neighboring gene RNA polymerase III subunit D

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables piRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables piRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in germ-line stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in piRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in piRNA-mediated gene silencing by mRNA destabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in piRNA-mediated gene silencing by mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of meiosis I ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulatory ncRNA-mediated gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulatory ncRNA-mediated gene silencing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in secondary piRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_positive_effect transposable element silencing by heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transposable element silencing by mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transposable element silencing by piRNA-mediated DNA methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transposable element silencing by piRNA-mediated DNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_positive_effect transposable element silencing by piRNA-mediated heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in P granule ISO
    Inferred from Sequence Orthology
    more info
     
    part_of PET complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatoid body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dense body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinucleolar chromocenter ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pi-body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    piwi-like protein 2
    Names
    piwi like homolog 2
    piwi-like 2
    NP_001100746.1
    XP_006252333.2
    XP_008769050.1
    XP_063130372.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107276.1NP_001100746.1  piwi-like protein 2

      See identical proteins and their annotated locations for NP_001100746.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473951
      UniProtKB/TrEMBL
      A6HTK3, D3ZRE1
      Related
      ENSRNOP00000013284.2, ENSRNOT00000013284.6
      Conserved Domains (3) summary
      cd02845
      Location:385502
      PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...
      cd04658
      Location:510954
      Piwi_piwi-like_Euk; PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of related ...
      pfam08699
      Location:337384
      ArgoL1; Argonaute linker 1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      51841104..51907729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770828.4XP_008769050.1  piwi-like protein 2 isoform X2

      Conserved Domains (4) summary
      cd02845
      Location:419536
      PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...
      cd04658
      Location:544950
      Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...
      pfam08699
      Location:371418
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:250346
      ArgoN; N-terminal domain of argonaute
    2. XM_006252271.4XP_006252333.2  piwi-like protein 2 isoform X1

      Related
      ENSRNOP00000105865.1, ENSRNOT00000140972.1
      Conserved Domains (4) summary
      cd02845
      Location:419536
      PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...
      cd04658
      Location:544988
      Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...
      pfam08699
      Location:371418
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:250346
      ArgoN; N-terminal domain of argonaute
    3. XM_063274302.1XP_063130372.1  piwi-like protein 2 isoform X3