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    Sgo1 shugoshin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363174, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sgo1provided by RGD
    Official Full Name
    shugoshin 1provided by RGD
    Primary source
    RGD:1593238
    See related
    EnsemblRapid:ENSRNOG00000022499 AllianceGenome:RGD:1593238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sgol1
    Summary
    Predicted to enable kinase binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore and mitotic sister chromatid cohesion, centromeric. Predicted to act upstream of or within centriole-centriole cohesion and meiotic chromosome segregation. Predicted to be located in several cellular components, including kinetochore; microtubule cytoskeleton; and nucleoplasm. Human ortholog(s) of this gene implicated in chronic atrial and intestinal dysrhythmia. Orthologous to human SGO1 (shugoshin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 73.1), Spleen (RPKM 53.3) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Sgo1 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (6908661..6943483, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (6672109..6687908, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (4420158..4435939)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene RAB5A, member RAS oncogene family Neighboring gene protein phosphatase 2C-like domain containing 1 Neighboring gene lysine acetyltransferase 2B Neighboring gene small nucleolar RNA SNORA48 Neighboring gene RIKEN cDNA 4932415M13 gene like Neighboring gene sulfotransferase 1C2-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinase binding  
    Component Evidence Code Pubs
    located_in centrosome  
    located_in chromosome, centromeric region  
    located_in condensed chromosome, centromeric region  
    located_in cytosol  
    located_in kinetochore  
    located_in nucleoplasm  
    located_in nucleus  
    located_in spindle pole  

    General protein information

    Preferred Names
    shugoshin 1
    Names
    shugoshin-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399344.1NP_001386273.1  shugoshin 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D4A624
      Conserved Domains (2) summary
      pfam07557
      Location:467489
      Shugoshin_C; Shugoshin C-terminus
      pfam07558
      Location:2266
      Shugoshin_N; Shugoshin N-terminal coiled-coil region
    2. NM_001399345.1NP_001386274.1  shugoshin 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D4A624
      Related
      ENSRNOP00000061236.3, ENSRNOT00000065721.4
      Conserved Domains (2) summary
      pfam07557
      Location:467489
      Shugoshin_C; Shugoshin C-terminus
      pfam07558
      Location:2266
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      6908661..6943483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267351.1XP_063123421.1  shugoshin 1 isoform X1

      UniProtKB/TrEMBL
      D4A624
    2. XM_063267352.1XP_063123422.1  shugoshin 1 isoform X1

      UniProtKB/TrEMBL
      D4A624
    3. XM_039084402.2XP_038940330.1  shugoshin 1 isoform X2

      Conserved Domains (2) summary
      pfam07557
      Location:466488
      Shugoshin_C; Shugoshin C-terminus
      pfam07558
      Location:2266
      Shugoshin_N; Shugoshin N-terminal coiled-coil region
    4. XM_063267353.1XP_063123423.1  shugoshin 1 isoform X2

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