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    Riox2 ribosomal oxygenase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Riox2provided by RGD
    Official Full Name
    ribosomal oxygenase 2provided by RGD
    Primary source
    RGD:708521
    See related
    EnsemblRapid:ENSRNOG00000001680 AllianceGenome:RGD:708521
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mina53
    Summary
    Predicted to enable several functions, including histone H3 demethylase activity; identical protein binding activity; and peptidyl-histidine dioxygenase activity. Predicted to be involved in chromatin remodeling; negative regulation of DNA-templated transcription; and ribosome biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleolus. Orthologous to human RIOX2 (ribosomal oxygenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 187.5), Heart (RPKM 90.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Riox2 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (54327311..54353989, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (40861365..40884782, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (43006190..43028722, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene Eph receptor A6 Neighboring gene U7 small nuclear RNA Neighboring gene ARF like GTPase 6 Neighboring gene crystallin beta-gamma domain containing 3 Neighboring gene NLR family, pyrin domain containing 4A, pseudogene 1 Neighboring gene uncharacterized LOC134480985 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho3 Neighboring gene olfactory receptor family 5 subfamily AC member 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel myc target gene, mina53, that is involved in cell proliferation. Tsuneoka M, et al. J Biol Chem, 2002 Sep 20. PMID 12091391
    2. Mina, an Il4 repressor, controls T helper type 2 bias. Okamoto M, et al. Nat Immunol, 2009 Aug. PMID 19561615, Free PMC Article
    3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
    4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105305

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K4 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-histidine dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-histidine dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal oxygenase 2
    Names
    MYC-induced nuclear antigen
    Mina-53
    bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
    histone lysine demethylase MINA
    myc induced nuclear antigen
    NP_695221.1
    XP_038943977.1
    XP_038943978.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153309.2 → NP_695221.1  ribosomal oxygenase 2

      See identical proteins and their annotated locations for NP_695221.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087650
      UniProtKB/Swiss-Prot
      Q8CFC1
      UniProtKB/TrEMBL
      A0A0A0MXT5, A6IQI7
      Related
      ENSRNOP00000081634.1, ENSRNOT00000100511.2
      Conserved Domains (1) summary
      pfam08007
      Location:51 → 364
      Cupin_4; Cupin superfamily protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      54327311..54353989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088049.2 → XP_038943977.1  ribosomal oxygenase 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8CFC1
      UniProtKB/TrEMBL
      A0A0A0MXT5, A6IQI7
      Conserved Domains (1) summary
      pfam08007
      Location:51 → 364
      Cupin_4; Cupin superfamily protein

    2. XM_039088050.2 → XP_038943978.1  ribosomal oxygenase 2 isoform X2

      Conserved Domains (1) summary
      pfam08007
      Location:84 → 300
      Cupin_4; Cupin superfamily protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFC1.1 GenPept UniProtKB/Swiss-Prot:Q8CFC1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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