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    Sv2c synaptic vesicle glycoprotein 2c [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29643, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sv2cprovided by RGD
    Official Full Name
    synaptic vesicle glycoprotein 2cprovided by RGD
    Primary source
    RGD:619718
    See related
    EnsemblRapid:ENSRNOG00000018094 AllianceGenome:RGD:619718
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in regulation of synaptic vesicle exocytosis. Located in synaptic vesicle. Is active in synaptic vesicle membrane. Orthologous to human SV2C (synaptic vesicle glycoprotein 2C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 91.5), Adrenal (RPKM 19.3) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Sv2c in Genome Data Viewer
    Location:
    2q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (28967631..29163168, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (27232933..27428479, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (26495757..26707691, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100552 Neighboring gene NADH:ubiquinone oxidoreductase subunit S6, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134485822 Neighboring gene uncharacterized LOC134485823

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables transmembrane transporter activity  
    Component Evidence Code Pubs
    is_active_in dopaminergic synapse  
    located_in synaptic vesicle PubMed 
    located_in synaptic vesicle  
    is_active_in synaptic vesicle membrane PubMed 
    is_active_in synaptic vesicle membrane  
    is_active_in synaptic vesicle membrane PubMed 

    General protein information

    Preferred Names
    synaptic vesicle glycoprotein 2C
    Names
    synaptic vesicle protein 2C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031593.2NP_113781.1  synaptic vesicle glycoprotein 2C

      See identical proteins and their annotated locations for NP_113781.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9Z2I6
      UniProtKB/TrEMBL
      A6I4Z9
      Related
      ENSRNOP00000024459.4, ENSRNOT00000024459.8
      Conserved Domains (3) summary
      cd06174
      Location:155719
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR01299
      Location:1727
      synapt_SV2; synaptic vesicle protein SV2
      pfam13576
      Location:507561
      Pentapeptide_3; Pentapeptide repeats (9 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      28967631..29163168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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