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    Noc2l NOC2-like nucleolar associated transcriptional repressor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313777, updated on 9-Dec-2024

    Summary

    Official Symbol
    Noc2lprovided by RGD
    Official Full Name
    NOC2-like nucleolar associated transcriptional repressorprovided by RGD
    Primary source
    RGD:1309387
    See related
    EnsemblRapid:ENSRNOG00000021392 AllianceGenome:RGD:1309387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309387
    Summary
    Predicted to enable several functions, including histone binding activity; nucleosome binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including cellular response to UV; negative regulation of apoptotic process; and regulation of gene expression. Predicted to be located in chromosome; cytosol; and nucleus. Predicted to be part of Noc1p-Noc2p complex and Noc2p-Noc3p complex. Predicted to be active in nucleolus and nucleoplasm. Orthologous to human NOC2L (NOC2 like nucleolar associated transcriptional repressor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 85.8), Thymus (RPKM 84.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Noc2l in Genome Data Viewer
    Location:
    5q36
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (172102369..172114168)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166820150..166831949)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173659796..173672699)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene PPARGC1 and ESRR induced regulator, muscle 1 Neighboring gene pleckstrin homology domain containing N1 Neighboring gene kelch-like family member 17 Neighboring gene sterile alpha motif domain containing 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC124822

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding  
    enables chromatin binding  
    enables histone binding  
    enables histone binding  
    enables nucleosome binding  
    enables transcription corepressor activity  
    enables transcription corepressor activity  
    Component Evidence Code Pubs
    part_of Noc1p-Noc2p complex  
    part_of Noc2p-Noc3p complex  
    located_in chromosome  
    located_in chromosome  
    located_in cytosol  
    located_in cytosol  
    is_active_in nucleolus  
    located_in nucleolus  
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    nucleolar complex protein 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033897.2NP_001029069.2  nucleolar complex protein 2 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      Q3T1I0
    2. NM_001399191.1NP_001386120.1  nucleolar complex protein 2 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      E9PTF3, Q3T1I0
      Related
      ENSRNOP00000059995.2, ENSRNOT00000066561.3
      Conserved Domains (1) summary
      pfam03715
      Location:328623
      Noc2; Noc2p family

    RNA

    1. NR_174167.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
    2. NR_174168.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      172102369..172114168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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