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    Igsf10 immunoglobulin superfamily, member 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310448, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Igsf10provided by RGD
    Official Full Name
    immunoglobulin superfamily, member 10provided by RGD
    Primary source
    RGD:735030
    See related
    EnsemblRapid:ENSRNOG00000013917 AllianceGenome:RGD:735030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in tissue regeneration. Acts upstream of or within ossification. Predicted to be active in extracellular region. Orthologous to human IGSF10 (immunoglobulin superfamily member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 247.1), Lung (RPKM 94.3) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Igsf10 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (145725868..145754850, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (143575710..143605044, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (149535199..149564180, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene purinergic receptor P2Y13 Neighboring gene purinergic receptor P2Y12 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene arylacetamide deacetylase-like 2 like Neighboring gene AADACL2 family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CMF608-a novel mechanical strain-induced bone-specific protein expressed in early osteochondroprogenitor cells. Segev O, et al. Bone, 2004 Feb. PMID 14962803
    2. IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty. Howard SR, et al. EMBO Mol Med, 2016 Jun. PMID 27137492, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ossification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tissue regeneration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    immunoglobulin superfamily member 10
    Names
    CMF608
    bone specific CMF608
    calvaria mechanical force protein 608

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198768.3 → NP_942063.2  immunoglobulin superfamily member 10 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q6WRH9
      UniProtKB/TrEMBL
      A6JVK7, G3V7S1
      Related
      ENSRNOP00000018629.4, ENSRNOT00000018628.7
      Conserved Domains (11) summary
      TIGR00864
      Location:192 → 273
      PCC; polycystin cation channel protein
      smart00013
      Location:28 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:219 → 243
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:2128 → 2202
      IG; Immunoglobulin
      smart00410
      Location:2027 → 2110
      IG_like; Immunoglobulin like
      sd00033
      Location:39 → 58
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05109
      Location:1139 → 1450
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13855
      Location:81 → 141
      LRR_8; Leucine rich repeat
      pfam13927
      Location:2405 → 2484
      Ig_3; Immunoglobulin domain
      cd00096
      Location:1930 → 1940
      Ig; putative Ig strand B [structural motif]
      cl11960
      Location:1640 → 1713
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      145725868..145754850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017590862.3 → XP_017446351.1  immunoglobulin superfamily member 10 isoform X2

      UniProtKB/Swiss-Prot
      Q6WRH9
      UniProtKB/TrEMBL
      A6JVK7, G3V7S1
      Conserved Domains (11) summary
      TIGR00864
      Location:192 → 273
      PCC; polycystin cation channel protein
      smart00013
      Location:28 → 60
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:219 → 243
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:2128 → 2202
      IG; Immunoglobulin
      smart00410
      Location:2027 → 2110
      IG_like; Immunoglobulin like
      sd00033
      Location:39 → 58
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05109
      Location:1139 → 1450
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13855
      Location:81 → 141
      LRR_8; Leucine rich repeat
      pfam13927
      Location:2405 → 2484
      Ig_3; Immunoglobulin domain
      cd00096
      Location:1930 → 1940
      Ig; putative Ig strand B [structural motif]
      cl11960
      Location:1640 → 1713
      Ig; Immunoglobulin domain

    2. XM_039102267.2 → XP_038958195.1  immunoglobulin superfamily member 10 isoform X1

      UniProtKB/Swiss-Prot
      Q6WRH9
      Conserved Domains (11) summary
      TIGR00864
      Location:242 → 323
      PCC; polycystin cation channel protein
      smart00013
      Location:78 → 110
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:269 → 293
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:2178 → 2252
      IG; Immunoglobulin
      smart00410
      Location:2077 → 2160
      IG_like; Immunoglobulin like
      sd00033
      Location:89 → 108
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05109
      Location:1189 → 1500
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13855
      Location:131 → 191
      LRR_8; Leucine rich repeat
      pfam13927
      Location:2455 → 2534
      Ig_3; Immunoglobulin domain
      cd00096
      Location:1980 → 1990
      Ig; putative Ig strand B [structural motif]
      cl11960
      Location:1690 → 1763
      Ig; Immunoglobulin domain

    3. XM_039102266.2 → XP_038958194.1  immunoglobulin superfamily member 10 isoform X1

      UniProtKB/Swiss-Prot
      Q6WRH9
      Conserved Domains (11) summary
      TIGR00864
      Location:242 → 323
      PCC; polycystin cation channel protein
      smart00013
      Location:78 → 110
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:269 → 293
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:2178 → 2252
      IG; Immunoglobulin
      smart00410
      Location:2077 → 2160
      IG_like; Immunoglobulin like
      sd00033
      Location:89 → 108
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05109
      Location:1189 → 1500
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13855
      Location:131 → 191
      LRR_8; Leucine rich repeat
      pfam13927
      Location:2455 → 2534
      Ig_3; Immunoglobulin domain
      cd00096
      Location:1980 → 1990
      Ig; putative Ig strand B [structural motif]
      cl11960
      Location:1690 → 1763
      Ig; Immunoglobulin domain

    4. XM_039102265.2 → XP_038958193.1  immunoglobulin superfamily member 10 isoform X1

      UniProtKB/Swiss-Prot
      Q6WRH9
      Conserved Domains (11) summary
      TIGR00864
      Location:242 → 323
      PCC; polycystin cation channel protein
      smart00013
      Location:78 → 110
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:269 → 293
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:2178 → 2252
      IG; Immunoglobulin
      smart00410
      Location:2077 → 2160
      IG_like; Immunoglobulin like
      sd00033
      Location:89 → 108
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05109
      Location:1189 → 1500
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13855
      Location:131 → 191
      LRR_8; Leucine rich repeat
      pfam13927
      Location:2455 → 2534
      Ig_3; Immunoglobulin domain
      cd00096
      Location:1980 → 1990
      Ig; putative Ig strand B [structural motif]
      cl11960
      Location:1690 → 1763
      Ig; Immunoglobulin domain

    5. XM_039102264.2 → XP_038958192.1  immunoglobulin superfamily member 10 isoform X1

      UniProtKB/Swiss-Prot
      Q6WRH9
      Related
      ENSRNOP00000112186.1, ENSRNOT00000136047.1
      Conserved Domains (11) summary
      TIGR00864
      Location:242 → 323
      PCC; polycystin cation channel protein
      smart00013
      Location:78 → 110
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:269 → 293
      LRRCT; Leucine rich repeat C-terminal domain
      smart00409
      Location:2178 → 2252
      IG; Immunoglobulin
      smart00410
      Location:2077 → 2160
      IG_like; Immunoglobulin like
      sd00033
      Location:89 → 108
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05109
      Location:1189 → 1500
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13855
      Location:131 → 191
      LRR_8; Leucine rich repeat
      pfam13927
      Location:2455 → 2534
      Ig_3; Immunoglobulin domain
      cd00096
      Location:1980 → 1990
      Ig; putative Ig strand B [structural motif]
      cl11960
      Location:1690 → 1763
      Ig; Immunoglobulin domain

    6. XM_039102268.2 → XP_038958196.1  immunoglobulin superfamily member 10 isoform X3

      UniProtKB/Swiss-Prot
      Q6WRH9
      Related
      ENSRNOP00000103563.1, ENSRNOT00000152418.1
      Conserved Domains (6) summary
      smart00409
      Location:357 → 437
      IG; Immunoglobulin
      smart00410
      Location:1903 → 1977
      IG_like; Immunoglobulin like
      pfam05109
      Location:914 → 1225
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam13927
      Location:2180 → 2259
      Ig_3; Immunoglobulin domain
      cd00096
      Location:2190 → 2194
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:1415 → 1488
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6WRH9.1 GenPept UniProtKB/Swiss-Prot:Q6WRH9

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