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    Hnrnpll heterogeneous nuclear ribonucleoprotein L-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313842, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hnrnpllprovided by RGD
    Official Full Name
    heterogeneous nuclear ribonucleoprotein L-likeprovided by RGD
    Primary source
    RGD:1305861
    See related
    EnsemblRapid:ENSRNOG00000006929 AllianceGenome:RGD:1305861
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hnrpll; RGD1305861
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of RNA splicing. Predicted to be active in nucleus and synapse. Orthologous to human HNRNPLL (heterogeneous nuclear ribonucleoprotein L like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 139.7), Kidney (RPKM 108.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hnrnpll in Genome Data Viewer
    Location:
    6q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20720013..20752803)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (14969953..15000574)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (2698983..2729715, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479103 Neighboring gene uncharacterized LOC134479102 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134479323 Neighboring gene uncharacterized LOC134479324 Neighboring gene atlastin GTPase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. Oberdoerffer S, et al. Science, 2008 Aug 1. PMID 18669861, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein L-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      20720013..20752803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_233805.11 → XP_233805.5  heterogeneous nuclear ribonucleoprotein L-like isoform X1

      See identical proteins and their annotated locations for XP_233805.5

      UniProtKB/TrEMBL
      D4A3E1
      Related
      ENSRNOP00000112228.1, ENSRNOT00000145980.1
      Conserved Domains (5) summary
      cd12700
      Location:385 → 455
      RRM3_hnRPLL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
      cd12705
      Location:501 → 585
      RRM4_hnRPLL; RNA recognition motif 4 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
      cd12781
      Location:122 → 205
      RRM1_hnRPLL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
      cd12786
      Location:214 → 309
      RRM2_hnRPLL; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)
      TIGR01649
      Location:123 → 590
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    2. XM_039113073.2 → XP_038969001.1  heterogeneous nuclear ribonucleoprotein L-like isoform X2

      Related
      ENSRNOP00000009175.6, ENSRNOT00000009175.8
      Conserved Domains (1) summary
      TIGR01649
      Location:123 → 566
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RNA

    1. XR_005505709.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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