U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Mapk8 mitogen-activated protein kinase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116554, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mapk8provided by RGD
    Official Full Name
    mitogen-activated protein kinase 8provided by RGD
    Primary source
    RGD:621506
    See related
    EnsemblRapid:ENSRNOG00000020155 AllianceGenome:RGD:621506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    JNK
    Summary
    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. [provided by RefSeq, Jul 2012]
    Expression
    Biased expression in Brain (RPKM 159.1), Muscle (RPKM 92.9) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mapk8 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (8645171..8728225, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (8638897..8721960, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (9620854..9709342, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Rho GTPase activating protein 22 Neighboring gene uncharacterized LOC134482457 Neighboring gene FERM and PDZ domain containing 2 Neighboring gene protein tyrosine phosphatase, non-receptor type 20

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables JUN kinase activity  
    enables JUN kinase activity PubMed 
    enables JUN kinase activity  
    enables JUN kinase activity  
    enables JUN kinase activity  
    enables JUN kinase activity PubMed 
    enables enzyme binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables histone deacetylase regulator activity  
    enables histone deacetylase regulator activity  
    enables kinase activity  
    enables kinesin binding PubMed 
    enables protein binding PubMed 
    enables protein kinase activity  
    enables protein phosphatase binding  
    enables protein phosphatase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase binding  
    enables protein serine/threonine kinase binding  
    enables protein serine/threonine/tyrosine kinase activity  
    Items 1 - 25 of 90
    Process Evidence Code Pubs
    involved_in JNK cascade  
    involved_in JNK cascade  
    involved_in JNK cascade  
    involved_in JNK cascade  
    acts_upstream_of_or_within JUN phosphorylation  
    involved_in JUN phosphorylation  
    involved_in SMAD protein signal transduction PubMed 
    acts_upstream_of apoptotic signaling pathway  
    involved_in cellular response to amino acid starvation  
    involved_in cellular response to amino acid starvation  
    involved_in cellular response to amyloid-beta PubMed 
    acts_upstream_of_or_within cellular response to hydrogen peroxide  
    involved_in cellular response to interleukin-1 PubMed 
    involved_in cellular response to lipopolysaccharide  
    acts_upstream_of_or_within cellular response to lipopolysaccharide  
    involved_in cellular response to mechanical stimulus  
    involved_in cellular response to mechanical stimulus  
    acts_upstream_of_or_within cellular response to nitric oxide  
    involved_in cellular response to oxidative stress  
    involved_in cellular response to oxygen-glucose deprivation PubMed 
    involved_in cellular response to oxygen-glucose deprivation PubMed 
    involved_in cellular response to reactive oxygen species  
    involved_in cellular response to reactive oxygen species  
    involved_in dendrite morphogenesis  
    involved_in energy homeostasis  
    involved_in glial cell apoptotic process PubMed 
    involved_in integrin-mediated signaling pathway  
    involved_in modulation of chemical synaptic transmission  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in neuron development PubMed 
    involved_in neuron migration  
    involved_in neuron projection development PubMed 
    acts_upstream_of_or_within neuronal stem cell population maintenance PubMed 
    acts_upstream_of_or_within neuronal stem cell population maintenance PubMed 
    acts_upstream_of_or_within ossification  
    acts_upstream_of_or_within peptidyl-serine phosphorylation  
    involved_in peptidyl-serine phosphorylation  
    involved_in peptidyl-serine phosphorylation  
    acts_upstream_of_or_within peptidyl-threonine phosphorylation  
    involved_in peptidyl-threonine phosphorylation  
    involved_in positive regulation of DNA replication PubMed 
    involved_in positive regulation of NLRP3 inflammasome complex assembly  
    involved_in positive regulation of NLRP3 inflammasome complex assembly  
    involved_in positive regulation of NLRP3 inflammasome complex assembly  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway  
    involved_in positive regulation of cardiac muscle cell apoptotic process PubMed 
    involved_in positive regulation of cell migration PubMed 
    involved_in positive regulation of cyclase activity  
    acts_upstream_of_or_within positive regulation of determination of dorsal identity  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of glial cell apoptotic process PubMed 
    involved_in positive regulation of microtubule polymerization PubMed 
    involved_in positive regulation of neuroblast proliferation PubMed 
    involved_in positive regulation of neuron apoptotic process PubMed 
    involved_in positive regulation of neuron migration PubMed 
    acts_upstream_of_or_within positive regulation of podosome assembly  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of protein metabolic process  
    involved_in positive regulation of protein metabolic process  
    involved_in positive regulation of protein ubiquitination  
    acts_upstream_of_or_within programmed necrotic cell death  
    acts_upstream_of_or_within protein localization to tricellular tight junction  
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in regulation of DNA-templated transcription PubMed 
    involved_in regulation of centrosome cycle PubMed 
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of dense core granule transport PubMed 
    acts_upstream_of_or_within regulation of gene expression  
    involved_in regulation of neuron differentiation PubMed 
    involved_in regulation of protein localization  
    involved_in regulation of protein localization  
    involved_in response to UV  
    acts_upstream_of_or_within response to UV  
    acts_upstream_of_or_within response to cadmium ion  
    involved_in response to hydrogen peroxide PubMed 
    involved_in response to mechanical stimulus  
    involved_in response to oxidative stress  
    involved_in response to steroid hormone PubMed 
    involved_in rhythmic process  
    involved_in stress-activated MAPK cascade  
    involved_in stress-activated MAPK cascade  
    involved_in type B pancreatic cell apoptotic process PubMed 
    Items 1 - 25 of 90
    Items 1 - 20 of 21
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse  
    located_in axon PubMed 
    located_in axon  
    located_in basal dendrite  
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite cytoplasm PubMed 
    located_in mitochondrion  
    located_in neuron projection  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perikaryon PubMed 
    located_in podosome  
    located_in synapse PubMed 
    located_in vesicle PubMed 
    Items 1 - 20 of 21

    General protein information

    Preferred Names
    mitogen-activated protein kinase 8
    Names
    MAP kinase 8
    MAPK 8
    SAPK gamma
    c-Jun N-terminal kinase 1
    c-jun NH2-terminal kinase
    p54 gamma
    stress-activated protein kinase JNK1
    NP_446281.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053829.2NP_446281.2  mitogen-activated protein kinase 8

      Status: REVIEWED

      Source sequence(s)
      AA963835, CB782828, DV724511, FM076271, JAXUCZ010000016, L27129
      UniProtKB/Swiss-Prot
      P49185
      Related
      ENSRNOP00000082511.1, ENSRNOT00000099742.2
      Conserved Domains (2) summary
      smart00220
      Location:26321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      8645171..8728225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.