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    Tbx4 T-box transcription factor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tbx4provided by RGD
    Official Full Name
    T-box transcription factor 4provided by RGD
    Primary source
    RGD:1309057
    See related
    EnsemblRapid:ENSRNOG00000003544 AllianceGenome:RGD:1309057
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including angiogenesis; embryonic hindlimb morphogenesis; and embryonic lung development. Predicted to act upstream of or within embryonic limb morphogenesis; lung development; and morphogenesis of an epithelium. Predicted to be located in chromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in arthropathy and ischiocoxopodopatellar syndrome. Orthologous to human TBX4 (T-box transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 129.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tbx4 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (71228145..71258222)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (70730686..70760829)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (73331864..73362784)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene BCAS3, microtubule associated cell migration factor Neighboring gene uncharacterized LOC134480844 Neighboring gene T-box transcription factor 2 Neighboring gene transfer RNA valine (anticodon AAC) 22 Neighboring gene BRCA1 interacting DNA helicase 1 Neighboring gene integrator complex subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Homozygous Null TBX4 Mutations Lead to Posterior Amelia with Pelvic and Pulmonary Hypoplasia. Kariminejad A, et al. Am J Hum Genet, 2019 Dec 5. PMID 31761294, Free PMC Article
    2. Mutations in the human TBX4 gene cause small patella syndrome. Bongers EM, et al. Am J Hum Genet, 2004 Jun. PMID 15106123, Free PMC Article
    3. Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth. Minguillon C, et al. Dev Cell, 2005 Jan. PMID 15621531
    4. T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung. Cebra-Thomas JA, et al. Dev Dyn, 2003 Jan. PMID 12508227
    5. Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois. Naiche LA, et al. Development, 2003 Jun. PMID 12736212

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic hindlimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic lung development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within morphogenesis of an epithelium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    T-box transcription factor TBX4
    Names
    T-box 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107034.1 → NP_001100504.1  T-box transcription factor TBX4

      See identical proteins and their annotated locations for NP_001100504.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HHQ2, D4A0A2
      Related
      ENSRNOP00000004736.2, ENSRNOT00000004736.5
      Conserved Domains (1) summary
      cd20189
      Location:75 → 259
      T-box_TBX4_5-like; DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      71228145..71258222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247036.5 → XP_006247098.1  T-box transcription factor TBX4 isoform X1

      See identical proteins and their annotated locations for XP_006247098.1

      Related
      ENSRNOP00000108109.1, ENSRNOT00000152651.1
      Conserved Domains (1) summary
      cd00182
      Location:74 → 263
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

    2. XM_039086044.2 → XP_038941972.1  T-box transcription factor TBX4 isoform X2

      Conserved Domains (1) summary
      cl00145
      Location:1 → 156
      T-box; DNA-binding domain of the T-box transcription factor family

    3. XM_006247037.5 → XP_006247099.1  T-box transcription factor TBX4 isoform X2

      See identical proteins and their annotated locations for XP_006247099.1

      Conserved Domains (1) summary
      cl00145
      Location:1 → 156
      T-box; DNA-binding domain of the T-box transcription factor family

    4. XM_063269092.1 → XP_063125162.1  T-box transcription factor TBX4 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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