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    Wdr62 WD repeat domain 62 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308492, updated on 27-Dec-2024

    Summary

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    Symbol
    Wdr62provided by RGD
    Full Name
    WD repeat domain 62provided by RGD
    Primary source
    RGD:1306714
    See related
    EnsemblRapid:ENSRNOG00000020807 AllianceGenome:RGD:1306714
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306714
    Summary
    Involved in several processes, including positive regulation of neuroblast proliferation; positive regulation of neuron migration; and regulation of centrosome cycle. Predicted to be located in cytosol; microtubule cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in intellectual disability; polymicrogyria; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to human WDR62 (WD repeat domain 62). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 92.6), Thymus (RPKM 20.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr62 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (94618992..94658097, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (85491531..85530643, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (90995545..91034592)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase II subunit I Neighboring gene ovo-like zinc finger 3 Neighboring gene uncharacterized LOC120096980 Neighboring gene THAP domain containing 8 Neighboring gene CAP-GLY domain containing linker protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel splice-site mutation in WDR62 revealed by whole-exome sequencing in a Sudanese family with primary microcephaly. Bastaki F, et al. Congenit Anom (Kyoto), 2016 May. PMID 26577670
    2. A novel single base pair duplication in WDR62 causes primary microcephaly. Rupp V, et al. BMC Med Genet, 2014 Oct 11. PMID 25303973, Free PMC Article
    3. The utility of exome sequencing for genetic diagnosis in a familial microcephaly epilepsy syndrome. McDonell LM, et al. BMC Neurol, 2014 Jan 31. PMID 24479948, Free PMC Article
    4. WDR62 missense mutation in a consanguineous family with primary microcephaly. Bacino CA, et al. Am J Med Genet A, 2012 Mar. PMID 22308068
    5. Mutations in WDR62 gene in Pakistani families with autosomal recessive primary microcephaly. Kousar R, et al. BMC Neurol, 2011 Oct 1. PMID 21961505, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 62
    Names
    WD repeat domain 62-like 1
    WD repeat-containing protein 62-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191623.2 → NP_001178552.2  WD repeat-containing protein 62

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1LRR4, F1M5K2
      Related
      ENSRNOP00000061740.2, ENSRNOT00000065011.4
      Conserved Domains (3) summary
      COG2319
      Location:437 → 745
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:538 → 579
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:493 → 745
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      94618992..94658097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228797.4 → XP_006228859.1  WD repeat-containing protein 62 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZG6, F1LRR4
      Related
      ENSRNOP00000071039.2, ENSRNOT00000082555.3
      Conserved Domains (3) summary
      COG2319
      Location:437 → 745
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:538 → 579
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:493 → 745
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_039111586.2 → XP_038967514.1  WD repeat-containing protein 62 isoform X1

      UniProtKB/TrEMBL
      F1LRR4
      Conserved Domains (3) summary
      PHA03247
      Location:1032 → 1438
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:538 → 579
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:493 → 745
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_039111587.2 → XP_038967515.1  WD repeat-containing protein 62 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:585 → 627
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:493 → 745
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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