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    Tfap2d transcription factor AP-2 delta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301284, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tfap2dprovided by RGD
    Official Full Name
    transcription factor AP-2 deltaprovided by RGD
    Primary source
    RGD:1304864
    See related
    EnsemblRapid:ENSRNOG00000011642 AllianceGenome:RGD:1304864
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tcfap2d
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within inferior colliculus development; negative regulation of neuron apoptotic process; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Orthologous to human TFAP2D (transcription factor AP-2 delta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 8.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tfap2d in Genome Data Viewer
    Location:
    9q13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (29177096..29241412)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (21680577..21744840)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (25304876..25365151)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene uncharacterized LOC134480350 Neighboring gene transcription factor AP-2 beta Neighboring gene uncharacterized LOC134480281

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel mouse AP-2 transcription factor, AP-2delta, with unique DNA binding and transactivation properties. Zhao F, et al. J Biol Chem, 2001 Nov 2. PMID 11522791
    2. AP-2δ is a crucial transcriptional regulator of the posterior midbrain. Hesse K, et al. PLoS One, 2011. PMID 21858141, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within inferior colliculus development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor AP-2-delta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106895.1 → NP_001100365.1  transcription factor AP-2-delta isoform 2

      See identical proteins and their annotated locations for NP_001100365.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473987
      UniProtKB/TrEMBL
      A6JJ69, D3ZYF2
      Related
      ENSRNOP00000063362.1, ENSRNOT00000065053.3
      Conserved Domains (1) summary
      pfam03299
      Location:43 → 243
      TF_AP-2; Transcription factor AP-2

    2. NM_001401661.1 → NP_001388590.1  transcription factor AP-2-delta isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZJN7
      Related
      ENSRNOP00000078078.1, ENSRNOT00000101279.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      29177096..29241412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083189.2 → XP_038939117.1  transcription factor AP-2-delta isoform X1

      Conserved Domains (1) summary
      pfam03299
      Location:215 → 409
      TF_AP-2; Transcription factor AP-2
    Nucleotide Protein Strain
    Heading Accession and Version

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