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    Poli DNA polymerase iota [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291526, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Poliprovided by RGD
    Official Full Name
    DNA polymerase iotaprovided by RGD
    Primary source
    RGD:1305212
    See related
    EnsemblRapid:ENSRNOG00000012111 AllianceGenome:RGD:1305212
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in translesion synthesis. Predicted to act upstream of or within cellular response to UV-C. Predicted to be located in cytoplasmic ribonucleoprotein granule and nuclear speck. Orthologous to human POLI (DNA polymerase iota). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 31.6), Thymus (RPKM 19.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Poli in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (66389214..66409734, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (64116774..64134373, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (65749107..65768805, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482986 Neighboring gene similar to human chromosome 18 open reading frame 54 Neighboring gene StAR-related lipid transfer domain containing 6 Neighboring gene methyl-CpG binding domain protein 2 Neighboring gene uncharacterized LOC134483047 Neighboring gene RNA polymerase II, I and III subunit K, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. 129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation. McDonald JP, et al. J Exp Med, 2003 Aug 18. PMID 12925679, Free PMC Article
    2. Participation of mouse DNA polymerase iota in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer. Dumstorf CA, et al. Proc Natl Acad Sci U S A, 2006 Nov 28. PMID 17114294, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to UV-C ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase iota
    Names
    polymerase (DNA directed), iota
    polymerase (DNA) iota
    NP_001099607.1
    XP_006254962.1
    XP_006254963.1
    XP_017456377.1
    XP_038952578.1
    XP_038952582.1
    XP_063133258.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106137.1 → NP_001099607.1  DNA polymerase iota

      See identical proteins and their annotated locations for NP_001099607.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473971
      UniProtKB/TrEMBL
      A0A8I6AJS8, A6IY06, D4A8I8
      Related
      ENSRNOP00000016189.5, ENSRNOT00000016189.8
      Conserved Domains (2) summary
      cd01703
      Location:51 → 431
      PolY_Pol_iota; DNA Polymerase iota
      COG0389
      Location:48 → 384
      DinP; Nucleotidyltransferase/DNA polymerase involved in DNA repair [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      66389214..66409734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277188.1 → XP_063133258.1  DNA polymerase iota isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJS8
      Related
      ENSRNOP00000093921.2, ENSRNOT00000112218.2

    2. XM_006254900.5 → XP_006254962.1  DNA polymerase iota isoform X3

      UniProtKB/TrEMBL
      A0A8I6AJS8
      Conserved Domains (1) summary
      cl12025
      Location:51 → 408
      PolY; Y-family of DNA polymerases

    3. XM_006254901.5 → XP_006254963.1  DNA polymerase iota isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZP81, A0A8I6AJS8
      Related
      ENSRNOP00000079848.1, ENSRNOT00000101965.2
      Conserved Domains (1) summary
      cl12025
      Location:34 → 389
      PolY; Y-family of DNA polymerases

    4. XM_039096650.2 → XP_038952578.1  DNA polymerase iota isoform X2

      UniProtKB/TrEMBL
      A0A8I6AJS8
      Conserved Domains (2) summary
      cd01703
      Location:50 → 430
      PolY_Pol_iota; DNA Polymerase iota
      cd19318
      Location:696 → 721
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1

    5. XM_017600888.3 → XP_017456377.1  DNA polymerase iota isoform X5

      UniProtKB/TrEMBL
      A0A8I6AJS8, A6IY07
      Conserved Domains (2) summary
      cd19318
      Location:634 → 659
      Rev1_UBM2; Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1
      cl28996
      Location:1 → 368
      PolY; Y-family of DNA polymerases

    6. XM_039096654.2 → XP_038952582.1  DNA polymerase iota isoform X6

      Conserved Domains (1) summary
      cl28996
      Location:51 → 351
      PolY; Y-family of DNA polymerases
    Nucleotide Protein Strain
    Heading Accession and Version

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