U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ndc80 NDC80 kinetochore complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301701, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    Ndc80provided by RGD
    Official Full Name
    NDC80 kinetochore complex componentprovided by RGD
    Primary source
    RGD:1310154
    See related
    EnsemblRapid:ENSRNOG00000013727 AllianceGenome:RGD:1310154
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kntc2
    Summary
    Predicted to enable several functions, including cyclin binding activity; identical protein binding activity; and kinetochore adaptor activity. Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore; microtubule cytoskeleton organization involved in mitosis; and positive regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to act upstream of or within several processes, including centrosome duplication; meiosis I cell cycle process; and skeletal muscle satellite cell proliferation. Predicted to be located in several cellular components, including centrosome; kinetochore; and nucleoplasm. Predicted to be part of Ndc80 complex. Orthologous to human NDC80 (NDC80 kinetochore complex component). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 95.9), Spleen (RPKM 54.1) and 8 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ndc80 in Genome Data Viewer
    Location:
    9q38
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (118853806..118887582, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (111407191..111440921, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (119837857..119871435, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene Y box binding protein 1, pseudogene 8 Neighboring gene structural maintenance of chromosomes flexible hinge domain containing 1 Neighboring gene uncharacterized LOC134480432 Neighboring gene methyltransferase 4, N6-adenosine Neighboring gene family with sequence similarity 114, member A1-like 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Hec1 inhibition alters spindle morphology and chromosome alignment in porcine oocytes. Wei X, et al. Mol Biol Rep, 2014 Aug. PMID 24752407
    2. Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis. Hayama S, et al. Cancer Res, 2006 Nov 1. PMID 17079454
    3. siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis. Kaneko N, et al. Biochem Biophys Res Commun, 2009 Dec 25. PMID 19878654
    4. Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubules. Iemura K, et al. Nat Commun, 2015 Mar 6. PMID 25743205
    5. Identification of two novel components of the human NDC80 kinetochore complex. Bharadwaj R, et al. J Biol Chem, 2004 Mar 26. PMID 14699129

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinetochore adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G2/MI transition of meiotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kinetochore organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal muscle satellite cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spindle assembly involved in female meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ndc80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    kinetochore protein NDC80 homolog
    Names
    NDC80 homolog, kinetochore complex component
    kinetochore associated 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001126270.3 → NP_001119742.2  kinetochore protein NDC80 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K254, B1WBY4, F7F189
      Related
      ENSRNOP00000072111.2, ENSRNOT00000080498.3
      Conserved Domains (2) summary
      COG5185
      Location:48 → 578
      HEC1; Protein involved in chromosome segregation, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning]
      pfam03801
      Location:51 → 206
      Ndc80_HEC; HEC/Ndc80p family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      118853806..118887582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767423.3 → XP_008765645.1  kinetochore protein NDC80 homolog isoform X1

      See identical proteins and their annotated locations for XP_008765645.1

      UniProtKB/TrEMBL
      A0A0G2K254, B1WBY4, F7F189
      Conserved Domains (2) summary
      COG5185
      Location:48 → 578
      HEC1; Protein involved in chromosome segregation, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning]
      pfam03801
      Location:51 → 206
      Ndc80_HEC; HEC/Ndc80p family

    2. XM_039083429.2 → XP_038939357.1  kinetochore protein NDC80 homolog isoform X1

      UniProtKB/TrEMBL
      A0A0G2K254, B1WBY4, F7F189
      Conserved Domains (2) summary
      COG5185
      Location:48 → 578
      HEC1; Protein involved in chromosome segregation, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning]
      pfam03801
      Location:51 → 206
      Ndc80_HEC; HEC/Ndc80p family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools