Ptchd1 patched domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptchd1provided by RGD
Official Full Name: patched domain containing 1provided by RGD
Primary source: RGD:1564527
See related: EnsemblRapid:ENSRNOG00000069252 AllianceGenome:RGD:1564527
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564527
Summary: Predicted to be involved in several processes, including smoothened signaling pathway; social behavior; and thalamus development. Predicted to act upstream of or within chemical synaptic transmission and memory. Predicted to be located in dendritic spine. Predicted to be active in plasma membrane and synapse. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human PTCHD1 (patched domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 59.5), Kidney (RPKM 7.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: Xq21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (43496907..43548413)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (39681910..39733416)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (42558912..42610430)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in cognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in cognition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within excitatory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inhibitory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-term memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within short-term memory	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in thalamus development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: patched domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191734.1 → NP_001178663.1 patched domain-containing protein 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I5ZYJ0, A6IPQ7

Related

ENSRNOP00000085114.1, ENSRNOT00000113700.2

Conserved Domains (2) summary

pfam02460
Location:105 → 851

Patched; Patched family

cl21543
Location:292 → 443

MMPL; MMPL family