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    Taf1a TATA-box binding protein associated factor, RNA polymerase I subunit A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Taf1aprovided by RGD
    Official Full Name
    TATA-box binding protein associated factor, RNA polymerase I subunit Aprovided by RGD
    Primary source
    RGD:1305698
    See related
    EnsemblRapid:ENSRNOG00000061139 AllianceGenome:RGD:1305698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in transcription by RNA polymerase I. Predicted to be located in microtubule cytoskeleton and nucleoplasm. Predicted to be part of RNA polymerase transcription factor SL1 complex. Orthologous to human TAF1A (TATA-box binding protein associated factor, RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 44.7), Thymus (RPKM 42.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Taf1a in Genome Data Viewer
    Location:
    13q26
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (97543772..97579742)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (95012160..95048131)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (101770278..101807975)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096335 Neighboring gene axin interactor, dorsalization associated Neighboring gene uncharacterized LOC108352586 Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4, pseudogene 4 Neighboring gene uncharacterized LOC120096336 Neighboring gene HHIP like 2 Neighboring gene uncharacterized LOC102555798

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TFIIB-related factors in RNA polymerase I transcription. Knutson BA, et al. Biochim Biophys Acta, 2013 Mar-Apr. PMID 22960599, Free PMC Article
    2. RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Schneider DA. Gene, 2012 Feb 10. PMID 21893173, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125031

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase I transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase transcription factor SL1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase transcription factor SL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TATA box-binding protein-associated factor RNA polymerase I subunit A
    Names
    TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A
    TATA box-binding protein-associated factor 1A
    TBP-associated factor 1A
    transcription initiation factor SL1/TIF-IB subunit A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037204.1 → NP_001032281.1  TATA box-binding protein-associated factor RNA polymerase I subunit A

      See identical proteins and their annotated locations for NP_001032281.1

      Status: PROVISIONAL

      Source sequence(s)
      BC107466
      UniProtKB/Swiss-Prot
      Q3B7U2
      UniProtKB/TrEMBL
      A6JGN7
      Conserved Domains (1) summary
      pfam14929
      Location:64 → 424
      TAF1_subA; TAF RNA Polymerase I subunit A

    2. NM_001429816.1 → NP_001416745.1  TATA box-binding protein-associated factor RNA polymerase I subunit A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q3B7U2
      UniProtKB/TrEMBL
      A6JGN7

    3. NM_001429817.1 → NP_001416746.1  TATA box-binding protein-associated factor RNA polymerase I subunit A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q3B7U2
      UniProtKB/TrEMBL
      A6JGN7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      97543772..97579742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090934.2 → XP_038946862.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X1

      UniProtKB/TrEMBL
      A6JGN7
      Conserved Domains (1) summary
      pfam14929
      Location:75 → 435
      TAF1_subA; TAF RNA Polymerase I subunit A

    2. XM_039090935.1 → XP_038946863.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X2

      Related
      ENSRNOP00000068899.2, ENSRNOT00000087784.3
      Conserved Domains (1) summary
      pfam14929
      Location:64 → 424
      TAF1_subA; TAF RNA Polymerase I subunit A

    3. XM_039090936.2 → XP_038946864.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X2

      Conserved Domains (1) summary
      pfam14929
      Location:64 → 424
      TAF1_subA; TAF RNA Polymerase I subunit A

    4. XM_039090937.2 → XP_038946865.1  TATA box-binding protein-associated factor RNA polymerase I subunit A isoform X3

      UniProtKB/TrEMBL
      A6JGN7
      Conserved Domains (1) summary
      pfam14929
      Location:1 → 347
      TAF1_subA; TAF RNA Polymerase I subunit A
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B7U2.1 GenPept UniProtKB/Swiss-Prot:Q3B7U2

    Gene LinkOut

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