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    Hbs1l HBS1-like translational GTPase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293408, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Hbs1lprovided by RGD
    Official Full Name
    HBS1-like translational GTPaseprovided by RGD
    Primary source
    RGD:1308509
    See related
    EnsemblRapid:ENSRNOG00000014531 AllianceGenome:RGD:1308509
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, no-go decay and rescue of stalled ribosome. Predicted to be located in cytoplasm. Predicted to be part of Dom34-Hbs1 complex. Predicted to be active in cytosolic ribosome. Human ortholog(s) of this gene implicated in beta thalassemia. Orthologous to human HBS1L (HBS1 like translational GTPase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 346.5), Heart (RPKM 343.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hbs1l in Genome Data Viewer
    Location:
    1p12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (17912139..17989651)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (16092529..16170082)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (16819170..16896234)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484958 Neighboring gene uncharacterized LOC134484960 Neighboring gene uncharacterized LOC134484961 Neighboring gene ribosomal protein L23a, pseudogene 3 Neighboring gene aldehyde dehydrogenase 8 family, member A1 Neighboring gene protein LEG1 homolog Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Association of SNP in exon 1 of HBS1L with hemoglobin F level in beta0-thalassemia/hemoglobin E. Pandit RA, et al. Int J Hematol, 2008 Nov. PMID 18839276
    2. Structural view on recycling of archaeal and eukaryotic ribosomes after canonical termination and ribosome rescue. Franckenberg S, et al. Curr Opin Struct Biol, 2012 Dec. PMID 23031510
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, no-go decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, no-go decay ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Dom34-Hbs1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Dom34-Hbs1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HBS1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011934.1 → NP_001011934.1  HBS1-like protein

      Status: PROVISIONAL

      Source sequence(s)
      BC079463
      UniProtKB/Swiss-Prot
      Q6AXM7
      UniProtKB/TrEMBL
      A0A8I6AGM5
      Related
      ENSRNOP00000095992.2, ENSRNOT00000116762.2
      Conserved Domains (5) summary
      cd01883
      Location:257 → 476
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:251 → 679
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam08938
      Location:45 → 119
      HBS1_N; HBS1 N-terminus
      cd16267
      Location:482 → 564
      HBS1-like_II; Domain II of Hbs1-like proteins
      cd04093
      Location:569 → 677
      HBS1_C_III; C-terminal domain of Hsp70 subfamily B suppressor 1 (HBS1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      17912139..17989651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285773.1 → XP_063141843.1  HBS1-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGM5

    2. XM_039106903.2 → XP_038962831.1  HBS1-like protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6AGM5, A6JPD9
      Related
      ENSRNOP00000019734.8, ENSRNOT00000019734.9
      Conserved Domains (2) summary
      COG5256
      Location:254 → 682
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam08938
      Location:45 → 119
      HBS1_N; HBS1 N-terminus

    3. XM_063285777.1 → XP_063141847.1  HBS1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A8I6AGM5

    4. XM_039106909.2 → XP_038962837.1  HBS1-like protein isoform X4

      UniProtKB/TrEMBL
      A0A8I6AGM5, A0A8I6GEG8
      Related
      ENSRNOP00000086834.1, ENSRNOT00000113225.2
      Conserved Domains (1) summary
      COG5256
      Location:189 → 617
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]

    5. XM_039106912.2 → XP_038962840.1  HBS1-like protein isoform X5

      UniProtKB/TrEMBL
      A0A8I6GEM5
      Related
      ENSRNOP00000086972.1, ENSRNOT00000114016.2
      Conserved Domains (1) summary
      pfam08938
      Location:45 → 119
      HBS1_N; HBS1 N-terminus

    6. XM_063285786.1 → XP_063141856.1  HBS1-like protein isoform X6

      UniProtKB/TrEMBL
      A6JPE2

    7. XM_063285789.1 → XP_063141859.1  HBS1-like protein isoform X6

      UniProtKB/TrEMBL
      A6JPE2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXM7.1 GenPept UniProtKB/Swiss-Prot:Q6AXM7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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