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    Mterf3 mitochondrial transcription termination factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299514, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mterf3provided by RGD
    Official Full Name
    mitochondrial transcription termination factor 3provided by RGD
    Primary source
    RGD:735158
    See related
    EnsemblRapid:ENSRNOG00000004492 AllianceGenome:RGD:735158
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cgi12; Mterfd1
    Summary
    Predicted to enable transcription cis-regulatory region binding activity. Predicted to be involved in mitochondrial ribosome assembly; mitochondrial transcription; and negative regulation of DNA-templated transcription. Predicted to be located in cytosol and mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human MTERF3 (mitochondrial transcription termination factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 139.6), Adrenal (RPKM 119.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mterf3 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (65711654..65729926, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63826418..63844747, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (71275544..71293842, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549197 Neighboring gene ubiquinol-cytochrome c reductase binding protein Neighboring gene 5S ribosomal RNA Neighboring gene phosphatidylserine synthase 1 Neighboring gene establishment of cohesion 1 homolog 2 (S. cerevisiae), pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MTERF3 is a negative regulator of mammalian mtDNA transcription. Park CB, et al. Cell, 2007 Jul 27. PMID 17662942
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC72611

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial ribosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transcription termination factor 3, mitochondrial
    Names
    MTERF domain containing 1
    mTERF domain-containing protein 1, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199387.1 → NP_955419.1  transcription termination factor 3, mitochondrial precursor

      See identical proteins and their annotated locations for NP_955419.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062080
      UniProtKB/Swiss-Prot
      Q6P6Q6
      UniProtKB/TrEMBL
      A6HQY0
      Related
      ENSRNOP00000006185.5, ENSRNOT00000006185.8
      Conserved Domains (1) summary
      cl19765
      Location:145 → 390
      mTERF

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      65711654..65729926 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241509.5 → XP_006241571.1  transcription termination factor 3, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl19765
      Location:151 → 284
      mTERF; mTERF

    2. XM_063263148.1 → XP_063119218.1  transcription termination factor 3, mitochondrial isoform X3

    3. XM_039078623.2 → XP_038934551.1  transcription termination factor 3, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl19765
      Location:22 → 242
      mTERF
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P6Q6.1 GenPept UniProtKB/Swiss-Prot:Q6P6Q6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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