Ccl26 C-C motif chemokine ligand 26 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccl26provided by RGD
Official Full Name: C-C motif chemokine ligand 26provided by RGD
Primary source: RGD:1587817
See related: AllianceGenome:RGD:1587817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable CCR3 chemokine receptor binding activity; CX3C chemokine receptor binding activity; and chemokine activity. Predicted to be involved in several processes, including leukocyte chemotaxis; positive regulation of GTPase activity; and positive regulation of actin filament polymerization. Predicted to be located in extracellular space. Used to study asthma. Human ortholog(s) of this gene implicated in asthma; eosinophilic esophagitis; and rhinitis. Orthologous to human CCL26 (C-C motif chemokine ligand 26). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 157.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (26745972..26750924)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (21109384..21114336)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (24157182..24161870)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCL26 levels in EAE rats were significantly increased. CCL26 levels in the serum and in brain tissues were positively correlated with the inflammatory scores. CCL26, which binds to the receptor CCR3, showed pro-inflammatory effects and aggravated tissue damage involving BBB impairment, especially in the acute stage of EAE.
Title: CCL26 and CCR3 are associated with the acute inflammatory response in the CNS in experimental autoimmune encephalomyelitis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CCR3 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables CX3C chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-C motif chemokine 26

Names: chemokine (C-C motif) ligand 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109488.2 → NP_001102958.1 C-C motif chemokine 26 precursor

See identical proteins and their annotated locations for NP_001102958.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6J0C7

Conserved Domains (1) summary

cd00272
Location:33 → 89

Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...