Afg3l2 AFG3 like matrix AAA peptidase subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Afg3l2provided by RGD
Official Full Name: AFG3 like matrix AAA peptidase subunit 2provided by RGD
Primary source: RGD:1305259
See related: EnsemblRapid:ENSRNOG00000017965 AllianceGenome:RGD:1305259
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP hydrolysis activity and metalloendopeptidase activity. Predicted to be involved in several processes, including calcium import into the mitochondrion; cellular response to glutathione; and proteolysis. Predicted to act upstream of or within several processes, including mitochondrion organization; nervous system development; and righting reflex. Predicted to be located in mitochondrion. Predicted to be part of m-AAA complex. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in optic atrophy 12; spastic ataxia; spastic ataxia 5; and spinocerebellar ataxia type 28. Orthologous to human AFG3L2 (AFG3 like matrix AAA peptidase subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 328.8), Adrenal (RPKM 223.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (63224163..63269000, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (60954268..60999110, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (63141418..63185510, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Netrin-1 attenuates cerebral ischemia/reperfusion injury by limiting mitochondrial ROS and Ca[2+] levels via activation of AKT phosphorylation and mitochondrial m-AAA protease AFG3L2.
Title: Netrin-1 attenuates cerebral ischemia/reperfusion injury by limiting mitochondrial ROS and Ca(2+) levels via activation of AKT phosphorylation and mitochondrial m-AAA protease AFG3L2.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables ATP-dependent peptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glutathione	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cristae formation	ISO Inferred from Sequence Orthology more info
involved_in membrane protein proteolysis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial protein processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial protein processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial protein quality control	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nerve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular junction development	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium import into the mitochondrion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within righting reflex	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of m-AAA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of m-AAA complex	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: AFG3-like protein 2

Names: AFG3 ATPase family member 3-like 2; AFG3-like AAA ATPase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134864.1 → NP_001128336.1 AFG3-like protein 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

A0A8I5ZLF3, F1LN92

Related

ENSRNOP00000024632.4, ENSRNOT00000024632.7

Conserved Domains (4) summary

TIGR01241
Location:252 → 745

FtsH_fam; ATP-dependent metalloprotease FtsH

pfam00004
Location:344 → 475

AAA; ATPase family associated with various cellular activities (AAA)

pfam01434
Location:561 → 743

Peptidase_M41; Peptidase family M41

pfam06480
Location:145 → 241

FtsH_ext; FtsH Extracellular

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

63224163..63269000 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096796.1 → XP_038952724.1 AFG3-like protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZLF3

Conserved Domains (2) summary

TIGR01241
Location:174 → 667

FtsH_fam; ATP-dependent metalloprotease FtsH

pfam06480
Location:67 → 163

FtsH_ext; FtsH Extracellular
XM_039096797.2 → XP_038952725.1 AFG3-like protein 2 isoform X2

Conserved Domains (1) summary

TIGR01241
Location:2 → 490

FtsH_fam; ATP-dependent metalloprotease FtsH

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001013140.1: Suppressed sequence

Description

NM_001013140.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.