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    Dnah8 dynein, axonemal, heavy chain 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 207117, updated on 9-Dec-2024

    Summary

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    Symbol
    Dnah8provided by RGD
    Full Name
    dynein, axonemal, heavy chain 8provided by RGD
    Primary source
    RGD:619986
    See related
    EnsemblRapid:ENSRNOG00000000542 AllianceGenome:RGD:619986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dlp8; Dnahc8
    Summary
    Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility and outer dynein arm assembly. Predicted to be located in axoneme. Predicted to be part of outer dynein arm. Predicted to be active in sperm flagellum. Human ortholog(s) of this gene implicated in spermatogenic failure 46. Orthologous to human DNAH8 (dynein axonemal heavy chain 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 127.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnah8 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    95
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (8694371..8948849)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (8692939..8946780)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (9301317..9560805)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548069 Neighboring gene glyoxalase 1 Neighboring gene uncharacterized LOC134483877 Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene uncharacterized LOC120098982 Neighboring gene uncharacterized LOC120098983 Neighboring gene U6 spliceosomal RNA Neighboring gene eukaryotic translation initiation factor 3, subunit I, pseudogene 4 Neighboring gene uncharacterized LOC134483876 Neighboring gene glucagon-like peptide 1 receptor Neighboring gene uromodulin-like 1 Neighboring gene uncharacterized LOC134483780

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ATP-driven remodeling of the linker domain in the dynein motor. Roberts AJ, et al. Structure, 2012 Oct 10. PMID 22863569, Free PMC Article
    2. The mouse t complex distorter/sterility candidate, Dnahc8, expresses a gamma-type axonemal dynein heavy chain isoform confined to the principal piece of the sperm tail. Samant SA, et al. Dev Biol, 2005 Sep 1. PMID 16054618
    3. Identification and molecular evolution of new dynein-like protein sequences in rat brain. Tanaka Y, et al. J Cell Sci, 1995 May. PMID 7657712
    4. Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia. Whitfield M, et al. Am J Hum Genet, 2019 Jul 3. PMID 31178125, Free PMC Article
    5. Substance dependence low-density whole genome association study in two distinct American populations. Yu Y, et al. Hum Genet, 2008 Jun. PMID 18438686, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of outer dynein arm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal heavy chain 8
    Names
    Atpase
    dynein heavy chain 8, axonemal
    dynein heavy chain 8, axonemal-like
    dynein, axon, heavy chain 8
    dynein, axonemal, heavy polypeptide 8
    dynein-like protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427092.1 → NP_001414021.1  dynein axonemal heavy chain 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      F1MAM6
      Related
      ENSRNOP00000000651.8, ENSRNOT00000000651.10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      8694371..8948849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099327.2 → XP_038955255.1  dynein axonemal heavy chain 8 isoform X1

      UniProtKB/TrEMBL
      F1MAM6
      Conserved Domains (4) summary
      COG5245
      Location:1328 → 4375
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:376 → 930
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:2045 → 2372
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4429 → 4724
      Dynein_C; Dynein heavy chain C-terminal domain

    2. XM_039099333.2 → XP_038955261.1  dynein axonemal heavy chain 8 isoform X2

      Conserved Domains (7) summary
      COG5245
      Location:1328 → 4334
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:376 → 930
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1505 → 1910
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:2045 → 2372
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam12780
      Location:2986 → 3248
      AAA_8; P-loop containing dynein motor region D4
      pfam12781
      Location:3636 → 3853
      AAA_9; ATP-binding dynein motor region D5
      pfam18199
      Location:4388 → 4683
      Dynein_C; Dynein heavy chain C-terminal domain

    3. XM_039099329.2 → XP_038955257.1  dynein axonemal heavy chain 8 isoform X1

      UniProtKB/TrEMBL
      F1MAM6
      Conserved Domains (4) summary
      COG5245
      Location:1328 → 4375
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:376 → 930
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:2045 → 2372
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4429 → 4724
      Dynein_C; Dynein heavy chain C-terminal domain

    4. XM_039099330.2 → XP_038955258.1  dynein axonemal heavy chain 8 isoform X1

      UniProtKB/TrEMBL
      F1MAM6
      Conserved Domains (4) summary
      COG5245
      Location:1328 → 4375
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:376 → 930
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:2045 → 2372
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4429 → 4724
      Dynein_C; Dynein heavy chain C-terminal domain

    5. XM_039099328.2 → XP_038955256.1  dynein axonemal heavy chain 8 isoform X1

      UniProtKB/TrEMBL
      F1MAM6
      Conserved Domains (4) summary
      COG5245
      Location:1328 → 4375
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:376 → 930
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:2045 → 2372
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:4429 → 4724
      Dynein_C; Dynein heavy chain C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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