Ptprh protein tyrosine phosphatase, receptor type, H [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptprhprovided by RGD
Official Full Name: protein tyrosine phosphatase, receptor type, Hprovided by RGD
Primary source: RGD:620553
See related: EnsemblRapid:ENSRNOG00000058906 AllianceGenome:RGD:620553
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bem2
Summary: Predicted to enable cadherin binding activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Predicted to be located in several cellular components, including cytosol; microvillus; and nuclear speck. Predicted to be part of receptor complex. Orthologous to human PTPRH (protein tyrosine phosphatase receptor type H). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 36.5), Uterus (RPKM 24.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (78272414..78318977)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (69243704..69276294)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (72809935..72859161)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase H

Names: brain-enriched membrane-associated protein tyrosine BEM-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429154.1 → NP_001416083.1 receptor-type tyrosine-protein phosphatase H isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_001429155.1 → NP_001416084.1 receptor-type tyrosine-protein phosphatase H isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2K754

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

78272414..78318977

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001191945.2: Suppressed sequence

Description

NM_001191945.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
NM_133592.1: Suppressed sequence

Description

NM_133592.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.