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    Reep2 receptor accessory protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 682105, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Reep2provided by RGD
    Official Full Name
    receptor accessory protein 2provided by RGD
    Primary source
    RGD:1586980
    See related
    EnsemblRapid:ENSRNOG00000049629 AllianceGenome:RGD:1586980
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable microtubule binding activity and taste receptor binding activity. Predicted to be involved in endoplasmic reticulum tubular network organization and regulation of intracellular transport. Predicted to act upstream of or within protein transport into membrane raft; sensory perception of bitter taste; and sensory perception of sweet taste. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 72A. Orthologous to human REEP2 (receptor accessory protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 204.2), Testes (RPKM 161.7) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Reep2 in Genome Data Viewer
    Location:
    18p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (26712236..26721275)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (26438130..26447165)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27632562..27641594)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348765 Neighboring gene family with sequence similarity 53, member C Neighboring gene lysine demethylase 3B Neighboring gene early growth response 1 Neighboring gene 5S ribosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of association of REEP2 with membranes leads to hereditary spastic paraplegia. Esteves T, et al. Am J Hum Genet, 2014 Feb 6. PMID 24388663, Free PMC Article
    2. REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity. Björk S, et al. PLoS One, 2013. PMID 24098485, Free PMC Article
    3. REEP2 enhances sweet receptor function by recruitment to lipid rafts. Ilegems E, et al. J Neurosci, 2010 Oct 13. PMID 20943918, Free PMC Article
    4. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Fong KW, et al. J Cell Sci, 2013 Feb 1. PMID 23264731, Free PMC Article
    5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables taste receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables taste receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport into membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of bitter taste ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of sweet taste ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    receptor expression-enhancing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048047.1 → NP_001041512.1  receptor expression-enhancing protein 2

      See identical proteins and their annotated locations for NP_001041512.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105630
      UniProtKB/TrEMBL
      A0A0G2K1L5, M0R8C1, Q0VGJ9
      Conserved Domains (1) summary
      pfam03134
      Location:19 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      26712236..26721275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277589.1 → XP_063133659.1  receptor expression-enhancing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K1L5

    2. XM_039097126.2 → XP_038953054.1  receptor expression-enhancing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K1L5
      Conserved Domains (1) summary
      pfam03134
      Location:19 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    3. XM_039097125.2 → XP_038953053.1  receptor expression-enhancing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K1L5
      Conserved Domains (1) summary
      pfam03134
      Location:56 → 131
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    4. XM_039097124.2 → XP_038953052.1  receptor expression-enhancing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K1L5
      Related
      ENSRNOP00000071891.2, ENSRNOT00000078969.3
      Conserved Domains (1) summary
      pfam03134
      Location:56 → 131
      TB2_DP1_HVA22; TB2/DP1, HVA22 family
    Nucleotide Protein Strain
    Heading Accession and Version

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