Junb JunB proto-oncogene, AP-1 transcription factor subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Junbprovided by RGD
Official Full Name: JunB proto-oncogene, AP-1 transcription factor subunitprovided by RGD
Primary source: RGD:2944
See related: EnsemblRapid:ENSRNOG00000065682 AllianceGenome:RGD:2944
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hypoxia; response to corticosterone; and response to progesterone. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor AP-1 complex. Biomarker of renal carcinoma. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and melanoma. Orthologous to human JUNB (JunB proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40081126..40082910)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23176265..23178049)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (26092972..26094756, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Based on these findings, miR-199a-5p induces apoptosis by targeting JunB.
Title: MicroRNA 199a-5p induces apoptosis by targeting JunB.
This study documents the active repressive influence of AP-1 onto MMP-9 transcriptional regulation by the engagement of JunB.
Title: JunB is a repressor of MMP-9 transcription in depolarized rat brain neurons.
Corticosterone treatment gave rise to a delayed and significant reduction of junB mRNA signals after 2 h in all hippocampal regions, which reversed to increase at 4 h.
Title: Time-course of immediate early gene expression in hippocampal subregions of adrenalectomized rats after acute corticosterone challenge.
Expressions of junB and c-fos were enhanced stepwise in 4NQO-induced carcinogenesis of rat tongue.
Title: Expressions of junB and c-fos are enhanced in 4-nitroquinoline 1-oxide-induced rat tongue cancers.
Dimerization with the Jun proteins inhibits c-Fos nuclear exit.
Title: Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic.
plays key role in remodelling phenomena of bone and cartilage
Title: Fos- and Jun-related transcription factors are involved in the signal transduction pathway of mechanical loading in condylar chondrocytes.
upon whisker stimulation by exploration of a novel, enriched environment, in the barrel cortex JunB, is differentially regulated in the temporal domain
Title: Expression of c-Fos, ICER, Krox-24 and JunB in the whisker-to-barrel pathway of rats: time course of induction upon whisker stimulation by tactile exploration of an enriched environment.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC302098P1 (e-PCR)
- UniSTS:272486

PMC152658P5 (e-PCR)
- UniSTS:271242

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within decidualization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic process involved in female pregnancy	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within labyrinthine layer blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to 4-nitroquinoline N-oxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to corticosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trophectodermal cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of transcription factor AP-1 complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor JunB

Names: Jun-B oncogene; jun B proto-oncogene; transcription factor AP-1 subunit JunB; transcription factor jun-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021836.2 → NP_068608.2 transcription factor JunB

See identical proteins and their annotated locations for NP_068608.2

Status: PROVISIONAL

Source sequence(s)

BC061862

UniProtKB/TrEMBL

A6IY42

Related

ENSRNOP00000107843.1, ENSRNOT00000108644.2

Conserved Domains (2) summary

cd14696
Location:267 → 326

bZIP_Jun; Basic leucine zipper (bZIP) domain of Jun proteins and similar proteins: a DNA-binding and dimerization domain

pfam03957
Location:5 → 254

Jun; Jun-like transcription factor