Map2k5 mitogen activated protein kinase kinase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Map2k5provided by RGD
Official Full Name: mitogen activated protein kinase kinase 5provided by RGD
Primary source: RGD:61890
See related: EnsemblRapid:ENSRNOG00000007926 AllianceGenome:RGD:61890
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mek5
Summary: Enables ATP binding activity and protein kinase activity. Involved in several processes, including ERK5 cascade; negative regulation of apoptotic process; and regulation of macromolecule metabolic process. Predicted to be located in spindle. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 59.4), Brain (RPKM 57.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (72520616..72748395, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (63625220..63852090, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (68055976..68282656, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that NSC23766-mediated Rac inhibition induces cerebellar granule neurons (CGNs) apoptosis through deactivation of prosurvival MAP Kinase Kinase 5 MEK5/ERK5 kinase signaling.
Title: Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades.
The p38-mitogen-activated protein kinase activated protein kinase 2 (MK2) pathway is a component of the signaling cascade regulating oligodendrocyte differentiation.
Title: Mitogen-activated protein kinase activated protein kinase 2 (MK2) participates in p38 MAPK regulated control of oligodendrocyte differentiation.
Several binding motifs for heat shock factor are dispersed in the mouse and rat promoter, and temperature shock transiently enhanced the MAP-kinase-activated kinase 5 transcript levels.
Title: The transcriptional regulation and cell-specific expression of the MAPK-activated protein kinase MK5.
Data show that the ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats.
Title: The ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats.
a novel interaction between the PKA pathway and MAPK signaling cascades and suggest that MK5, but not MK2, is implicated in PKA-induced microfilament rearrangement.
Title: Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5.
MEK5-ERK5 cascade plays a pivotal role in the biliary dysgenesis of polycystic kidney rats, and also provide insights into the pathogenesis of Caroli's disease.
Title: Activation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli's disease.
MEK5 and big MAP kinase 1 (BMK1) function downstream of MEKK3 in a signaling cascade that induces calcineurin activity through phosphorylation of MCIP1
Title: Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1.
hypertrophic responses to cardiotrophin-1 is mitogen activated protein kinase kinase 5-mitogen-activated protein kinase 7 pathway
Title: Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes.
nuclear localization of MEK5 and ERK5 is different from that of ERK1/2 and MEK1/2 in resting cells, indicating that each MAPK cascade uses distinct mechanisms
Title: MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.

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General gene information

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Markers

UniSTS:469815 (e-PCR)
- UniSTS:469815

Map2k5 (e-PCR), detects polymorphism
- UniSTS:469815

RH138128 (e-PCR)
- UniSTS:220215

D0Mco41 (e-PCR)
- UniSTS:518979

RH138410 (e-PCR)
- UniSTS:220497

BF394715 (e-PCR)
- UniSTS:244834

D8Got101 (e-PCR)
- UniSTS:112845

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	TAS Traceable Author Statement more info
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase activity	IC Inferred by Curator more info	PubMed
enables MAP kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERK5 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in MAPK cascade	IC Inferred by Curator more info	PubMed
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-8 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of response to cytokine stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dual specificity mitogen-activated protein kinase kinase 5

Names: MAP kinase kinase 5; MAPK/ERK kinase 5; MAPKK 5; MEK 5

NP_001029159.1

EC 2.7.12.2

NP_058942.1

EC 2.7.12.2

XP_006243291.1

EC 2.7.12.2

XP_017450990.1

EC 2.7.12.2

XP_038936881.1

EC 2.7.12.2

XP_038936882.1

EC 2.7.12.2

XP_038936883.1

EC 2.7.12.2

XP_038936884.1

EC 2.7.12.2

XP_038936888.1

EC 2.7.12.2

XP_063121088.1

EC 2.7.12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033987.1 → NP_001029159.1 dual specificity mitogen-activated protein kinase kinase 5 isoform a

See identical proteins and their annotated locations for NP_001029159.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).

Source sequence(s)

BC078860

UniProtKB/Swiss-Prot

Q62862, Q62863, Q62864

UniProtKB/TrEMBL

A0A8L2R4U8, A6J595

Related

ENSRNOP00000050528.2, ENSRNOT00000051558.6

Conserved Domains (2) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cd06619
Location:164 → 442

PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
NM_017246.2 → NP_058942.1 dual specificity mitogen-activated protein kinase kinase 5 isoform b

See identical proteins and their annotated locations for NP_058942.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a.

Source sequence(s)

BC078860, U37464

UniProtKB/TrEMBL

A0A8L2R4U8, A6J594

Related

ENSRNOP00000010991.6, ENSRNOT00000010991.8

Conserved Domains (3) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cd06619
Location:164 → 432

PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5

smart00220
Location:170 → 409

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

72520616..72748395 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595501.3 → XP_017450990.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X6

UniProtKB/TrEMBL

A0A8L2R4U8

Related

ENSRNOP00000083354.2, ENSRNOT00000114643.2
XM_006243229.5 → XP_006243291.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X5

UniProtKB/TrEMBL

A0A8L2R4U8

Conserved Domains (2) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cd06619
Location:164 → 433

PKc_MKK5; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5
XM_039080955.2 → XP_038936883.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X3

UniProtKB/TrEMBL

A0A8L2R4U8

Conserved Domains (2) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cl21453
Location:164 → 391

PKc_like; Protein Kinases, catalytic domain
XM_039080956.2 → XP_038936884.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X4

UniProtKB/TrEMBL

A0A8L2R4U8

Conserved Domains (2) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cl21453
Location:164 → 381

PKc_like; Protein Kinases, catalytic domain
XM_039080954.2 → XP_038936882.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X2

UniProtKB/TrEMBL

A0A8L2R4U8

Conserved Domains (2) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cl21453
Location:164 → 392

PKc_like; Protein Kinases, catalytic domain
XM_039080953.2 → XP_038936881.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X1

UniProtKB/TrEMBL

A0A8L2R4U8

Conserved Domains (2) summary

cd06395
Location:17 → 107

PB1_Map2k5; PB1 domain is essential part of the mitogen-activated protein kinase kinase 5 (Map2k5, alias MEK5) one of the key member of the signaling kinases cascade which involved in angiogenesis and early cardiovascular development. The PB1 domain of Map2k5 ...

cl21453
Location:164 → 401

PKc_like; Protein Kinases, catalytic domain
XM_039080960.2 → XP_038936888.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X7

Conserved Domains (1) summary

cl21453
Location:75 → 312

PKc_like; Protein Kinases, catalytic domain
XM_063265018.1 → XP_063121088.1 dual specificity mitogen-activated protein kinase kinase 5 isoform X8