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    Thrap3 thyroid hormone receptor associated protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313591, updated on 4-Jan-2025

    Summary

    Official Symbol
    Thrap3provided by RGD
    Official Full Name
    thyroid hormone receptor associated protein 3provided by RGD
    Primary source
    RGD:1306129
    See related
    EnsemblRapid:ENSRNOG00000009977 AllianceGenome:RGD:1306129
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including nuclear thyroid hormone receptor binding activity; phosphoprotein binding activity; and transcription coactivator activity. Predicted to be involved in circadian rhythm; positive regulation of circadian rhythm; and regulation of gene expression. Predicted to be located in nuclear speck. Predicted to be part of exon-exon junction complex and mediator complex. Orthologous to human THRAP3 (thyroid hormone receptor associated protein 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 409.0), Spleen (RPKM 333.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Thrap3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (143729821..143772105, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (138445284..138487544, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (144178248..144221318, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351032 Neighboring gene eva-1 homolog B Neighboring gene SH3 domain containing 21 Neighboring gene uncharacterized LOC120103176 Neighboring gene MAP7 domain containing 1 Neighboring gene uncharacterized LOC134486990

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Clone Names

    • MGC94882

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables mRNA binding  
    enables nuclear thyroid hormone receptor binding  
    enables phosphoprotein binding  
    enables phosphoprotein binding  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables transcription coregulator activity  
    enables transcription coregulator activity  
    Process Evidence Code Pubs
    involved_in RNA splicing  
    involved_in circadian rhythm  
    involved_in mRNA processing  
    involved_in mRNA stabilization  
    involved_in mRNA stabilization  
    involved_in mRNA transport  
    involved_in nuclear-transcribed mRNA catabolic process  
    involved_in nuclear-transcribed mRNA catabolic process  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of circadian rhythm  
    involved_in positive regulation of circadian rhythm  
    involved_in positive regulation of mRNA splicing, via spliceosome  
    involved_in positive regulation of mRNA splicing, via spliceosome  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in regulation of alternative mRNA splicing, via spliceosome  
    involved_in regulation of alternative mRNA splicing, via spliceosome  
    involved_in regulation of translation  
    Component Evidence Code Pubs
    located_in cytoplasm  
    part_of exon-exon junction complex  
    part_of exon-exon junction complex  
    part_of exon-exon junction complex  
    part_of mediator complex  
    part_of mediator complex  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    thyroid hormone receptor-associated protein 3
    Names
    thyroid hormone receptor-associated protein complex 150 kDa component
    trap150

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009693.1NP_001009693.1  thyroid hormone receptor-associated protein 3

      See identical proteins and their annotated locations for NP_001009693.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088415
      UniProtKB/Swiss-Prot
      Q5M7V8
      UniProtKB/TrEMBL
      A0A8I5ZUG9
      Related
      ENSRNOP00000085793.2, ENSRNOT00000106551.2
      Conserved Domains (1) summary
      pfam15440
      Location:191766
      THRAP3_BCLAF1; THRAP3/BCLAF1 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      143729821..143772105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238867.4XP_006238929.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZUG9, A0A8I6A105
      Conserved Domains (1) summary
      pfam15440
      Location:343595
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    2. XM_039110014.2XP_038965942.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5M7V8
      UniProtKB/TrEMBL
      A0A8I5ZUG9
      Conserved Domains (1) summary
      pfam15440
      Location:191766
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    3. XM_039110015.2XP_038965943.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5M7V8
      UniProtKB/TrEMBL
      A0A8I5ZUG9
      Conserved Domains (1) summary
      pfam15440
      Location:191766
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    4. XM_008764021.4XP_008762243.1  thyroid hormone receptor-associated protein 3 isoform X1

      See identical proteins and their annotated locations for XP_008762243.1

      UniProtKB/Swiss-Prot
      Q5M7V8
      UniProtKB/TrEMBL
      A0A8I5ZUG9
      Conserved Domains (1) summary
      pfam15440
      Location:191766
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    5. XM_063287755.1XP_063143825.1  thyroid hormone receptor-associated protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZUG9, A0A8I6A105
    6. XM_008764022.4XP_008762244.1  thyroid hormone receptor-associated protein 3 isoform X1

      See identical proteins and their annotated locations for XP_008762244.1

      UniProtKB/Swiss-Prot
      Q5M7V8
      UniProtKB/TrEMBL
      A0A8I5ZUG9
      Conserved Domains (1) summary
      pfam15440
      Location:191766
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    7. XM_063287753.1XP_063143823.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5M7V8
      UniProtKB/TrEMBL
      A0A8I5ZUG9
    8. XM_063287754.1XP_063143824.1  thyroid hormone receptor-associated protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q5M7V8
      UniProtKB/TrEMBL
      A0A8I5ZUG9
    9. XM_039110018.2XP_038965946.1  thyroid hormone receptor-associated protein 3 isoform X4

      Conserved Domains (1) summary
      pfam15440
      Location:3484
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
    10. XM_063287756.1XP_063143826.1  thyroid hormone receptor-associated protein 3 isoform X5

    11. XM_039110017.2XP_038965945.1  thyroid hormone receptor-associated protein 3 isoform X3

      Conserved Domains (1) summary
      pfam15440
      Location:191704
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
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