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    Osbpl10 oxysterol binding protein-like 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316039, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Osbpl10provided by RGD
    Official Full Name
    oxysterol binding protein-like 10provided by RGD
    Primary source
    RGD:1561652
    See related
    EnsemblRapid:ENSRNOG00000011435 AllianceGenome:RGD:1561652
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561652
    Summary
    Predicted to enable cholesterol binding activity and phosphatidylserine binding activity. Predicted to be involved in lipid transport. Predicted to be active in cytosol and membrane. Orthologous to human OSBPL10 (oxysterol binding protein like 10). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Testes (RPKM 53.8), Brain (RPKM 20.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Osbpl10 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (123536818..123796822)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (114661050..114918664)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (123029722..123303553)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480243 Neighboring gene U6 spliceosomal RNA Neighboring gene CKLF-like MARVEL transmembrane domain containing 8 Neighboring gene glycerol-3-phosphate dehydrogenase 1 like Neighboring gene uncharacterized LOC108351789 Neighboring gene uncharacterized LOC120094279 Neighboring gene STT3 oligosaccharyltransferase complex catalytic subunit B Neighboring gene uncharacterized LOC102557192

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins. Maeda K, et al. Nature, 2013 Sep 12. PMID 23934110
    2. The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. Suchanek M, et al. Biochem J, 2007 Aug 1. PMID 17428193, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427692.1 → NP_001414621.1  oxysterol-binding protein-related protein 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      F1LWM8
      Related
      ENSRNOP00000015643.8, ENSRNOT00000015643.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      123536818..123796822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596141.3 → XP_017451630.1  oxysterol-binding protein-related protein 10 isoform X1

      Related
      ENSRNOP00000110046.1, ENSRNOT00000141356.1

    2. XM_063265640.1 → XP_063121710.1  oxysterol-binding protein-related protein 10 isoform X2

    3. XM_063265649.1 → XP_063121719.1  oxysterol-binding protein-related protein 10 isoform X9

    4. XM_063265648.1 → XP_063121718.1  oxysterol-binding protein-related protein 10 isoform X8

    5. XM_039082690.2 → XP_038938618.1  oxysterol-binding protein-related protein 10 isoform X7

      Conserved Domains (1) summary
      cd13291
      Location:79 → 185
      PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain

    6. XM_063265641.1 → XP_063121711.1  oxysterol-binding protein-related protein 10 isoform X3

      UniProtKB/TrEMBL
      A6I3R0

    7. XM_063265644.1 → XP_063121714.1  oxysterol-binding protein-related protein 10 isoform X3

      UniProtKB/TrEMBL
      A6I3R0
      Related
      ENSRNOP00000110128.1, ENSRNOT00000161384.1

    8. XM_063265643.1 → XP_063121713.1  oxysterol-binding protein-related protein 10 isoform X3

      UniProtKB/TrEMBL
      A6I3R0

    9. XM_063265642.1 → XP_063121712.1  oxysterol-binding protein-related protein 10 isoform X3

      UniProtKB/TrEMBL
      A6I3R0

    10. XM_063265645.1 → XP_063121715.1  oxysterol-binding protein-related protein 10 isoform X4

      UniProtKB/TrEMBL
      A6I3R1

    11. XM_063265646.1 → XP_063121716.1  oxysterol-binding protein-related protein 10 isoform X5

      UniProtKB/TrEMBL
      A6I3R1

    12. XM_063265647.1 → XP_063121717.1  oxysterol-binding protein-related protein 10 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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