Fkrp fukutin related protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fkrpprovided by RGD
Official Full Name: fukutin related proteinprovided by RGD
Primary source: RGD:1305852
See related: EnsemblRapid:ENSRNOG00000016055 AllianceGenome:RGD:1305852
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including dystroglycan binding activity; identical protein binding activity; and laminin binding activity. Predicted to be involved in protein O-linked mannosylation and protein tetramerization. Predicted to act upstream of or within several processes, including monocarboxylic acid metabolic process; nervous system development; and skeletal muscle organ development. Predicted to be located in several cellular components, including Golgi membrane; rough endoplasmic reticulum; and sarcolemma. Predicted to be active in Golgi apparatus and skeletal muscle myofibril. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and muscular dystrophy (multiple). Orthologous to human FKRP (fukutin related protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 59.4), Heart (RPKM 50.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (86607769..86615045, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (77479641..77486954, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (78733461..78740803, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dystroglycan binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables phosphotransferase activity, for other substituted phosphate groups	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within basement membrane organization	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within connective tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within connective tissue replacement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within creatine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within diaphragm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within filtration diaphragm assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycolytic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within localization of cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maintenance of protein localization in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle structure development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oxygen metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pentitol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pentose metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked mannosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein O-linked mannosylation	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked mannosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein glycosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein modification process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein tetramerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reelin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory system process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to alcohol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to glucocorticoid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle fiber differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in rough endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
is_active_in skeletal muscle myofibril	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribitol 5-phosphate transferase FKRP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025678.1 → NP_001020849.1 ribitol 5-phosphate transferase FKRP

See identical proteins and their annotated locations for NP_001020849.1

Status: PROVISIONAL

Source sequence(s)

BC099170

UniProtKB/TrEMBL

A0A8I6GI25, A6J8C8, Q4KLJ4

Related

ENSRNOP00000021586.4, ENSRNOT00000021586.6

Conserved Domains (2) summary

PRK09382
Location:67 → 163

ispDF; bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional

cl01378
Location:334 → 371

LicD; LicD family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

86607769..86615045 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228414.5 → XP_006228476.1 ribitol 5-phosphate transferase FKRP isoform X1

See identical proteins and their annotated locations for XP_006228476.1

UniProtKB/TrEMBL

A0A8I6GI25, A6J8C8, Q4KLJ4

Related

ENSRNOP00000107417.1, ENSRNOT00000124220.1

Conserved Domains (2) summary

PRK09382
Location:67 → 163

ispDF; bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional

cl01378
Location:334 → 371

LicD; LicD family
XM_006228415.5 → XP_006228477.1 ribitol 5-phosphate transferase FKRP isoform X1

See identical proteins and their annotated locations for XP_006228477.1

UniProtKB/TrEMBL

A0A8I6GI25, A6J8C8, Q4KLJ4

Related

ENSRNOP00000103969.1, ENSRNOT00000138144.1

Conserved Domains (2) summary

PRK09382
Location:67 → 163

ispDF; bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional

cl01378
Location:334 → 371

LicD; LicD family