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    Alkbh5 alkB homolog 5, RNA demethylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303193, updated on 9-Dec-2024

    Summary

    Official Symbol
    Alkbh5provided by RGD
    Official Full Name
    alkB homolog 5, RNA demethylaseprovided by RGD
    Primary source
    RGD:1309496
    See related
    EnsemblRapid:ENSRNOG00000028341 AllianceGenome:RGD:1309496
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309496
    Summary
    Predicted to enable mRNA N6-methyladenosine dioxygenase activity and molecular condensate scaffold activity. Predicted to be involved in several processes, including post-transcriptional regulation of gene expression; response to hypoxia; and spermatogenesis. Predicted to act upstream of or within regulation of mRNA export from nucleus and regulation of mRNA processing. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Predicted to be active in paraspeckles. Orthologous to human ALKBH5 (alkB homolog 5, RNA demethylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 215.5), Kidney (RPKM 214.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Alkbh5 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45844411..45865853)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45344888..45366331)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46906314..46927759)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene developmentally regulated GTP binding protein 2 Neighboring gene myosin XVA Neighboring gene U7 small nuclear RNA Neighboring gene ribosomal protein L17 like 5 Neighboring gene LLGL scribble cell polarity complex component 1 Neighboring gene small nucleolar RNA SNORA15 Neighboring gene FLII, actin remodeling protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2-oxoglutarate-dependent dioxygenase activity  
    enables 2-oxoglutarate-dependent dioxygenase activity  
    NOT enables lysophospholipase activity  
    enables mRNA N6-methyladenosine dioxygenase activity  
    enables mRNA N6-methyladenosine dioxygenase activity  
    enables metal ion binding  
    enables molecular condensate scaffold activity  
    enables molecular condensate scaffold activity  
    enables oxidative RNA demethylase activity  
    Process Evidence Code Pubs
    involved_in cell differentiation  
    acts_upstream_of gamma-delta T cell proliferation  
    involved_in mRNA destabilization  
    involved_in mRNA destabilization  
    involved_in mRNA processing  
    involved_in membraneless organelle assembly  
    involved_in membraneless organelle assembly  
    acts_upstream_of_or_within regulation of mRNA export from nucleus  
    acts_upstream_of_or_within regulation of mRNA export from nucleus  
    acts_upstream_of_or_within regulation of mRNA processing  
    acts_upstream_of_or_within regulation of mRNA processing  
    involved_in regulation of mRNA stability  
    involved_in regulation of mRNA stability  
    involved_in regulation of translation  
    involved_in regulation of translation  
    involved_in response to hypoxia  
    involved_in response to hypoxia  
    involved_in spermatogenesis  
    involved_in spermatogenesis  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in cytosol  
    located_in cytosol  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    is_active_in paraspeckles  
    is_active_in paraspeckles  

    General protein information

    Preferred Names
    RNA demethylase ALKBH5
    Names
    AlkB family member 5, RNA demethylase
    alkB, alkylation repair homolog 5
    alkylated DNA repair protein alkB homolog 5
    alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
    NP_001178572.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191643.1NP_001178572.1  RNA demethylase ALKBH5

      See identical proteins and their annotated locations for NP_001178572.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      D3ZKD3
      Related
      ENSRNOP00000034155.3, ENSRNOT00000034006.7
      Conserved Domains (1) summary
      cl21496
      Location:137271
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      45844411..45865853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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