Msl2 MSL complex subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Msl2provided by RGD
Full Name: MSL complex subunit 2provided by RGD
Primary source: RGD:1310355
See related: EnsemblRapid:ENSRNOG00000023021 AllianceGenome:RGD:1310355
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Msl2l1; RGD1310355
Summary: Predicted to enable histone H2B ubiquitin ligase activity and promoter-enhancer loop anchoring activity. Predicted to be involved in DNA damage response; protein monoubiquitination; and regulation of gene expression. Predicted to be part of MSL complex. Predicted to be active in chromatin and nucleus. Orthologous to human MSL2 (MSL complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 172.1), Spleen (RPKM 150.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (110555579..110642096)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (101676605..101702818)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (109456097..109480143)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AA956252 (e-PCR)
- UniSTS:261163

RH127956 (e-PCR)
- UniSTS:211266

RH140126 (e-PCR)
- UniSTS:222205

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone H2B ubiquitin ligase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-enhancer loop anchoring activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in epigenetic regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MSL complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MSL complex	ISO Inferred from Sequence Orthology more info
is_active_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase MSL2

Names: male-specific lethal 2 homolog; male-specific lethal 2-like 1

NP_001388814.1

EC 2.3.2.27

XP_038938512.1

EC 2.3.2.27

XP_038938513.1

EC 2.3.2.27

XP_063121668.1

EC 2.3.2.27

XP_063121669.1

EC 2.3.2.27

XP_063121670.1

EC 2.3.2.27

XP_063121671.1

EC 2.3.2.27

XP_063121672.1

EC 2.3.2.27

XP_063121673.1

EC 2.3.2.27

XP_063121674.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401885.1 → NP_001388814.1 E3 ubiquitin-protein ligase MSL2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6AT15, A6I2G4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

110555579..110642096

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082584.2 → XP_038938512.1 E3 ubiquitin-protein ligase MSL2 isoform X2

UniProtKB/TrEMBL

A0A8I6AT15

Conserved Domains (3) summary

TIGR03551
Location:203 → 245

F420_cofH; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit

pfam16682
Location:414 → 468

MSL2-CXC; CXC domain of E3 ubiquitin-protein ligase MSL2

pfam16685
Location:3 → 70

zf-RING_10; zinc RING finger of MSL2
XM_063265600.1 → XP_063121670.1 E3 ubiquitin-protein ligase MSL2 isoform X1
XM_063265601.1 → XP_063121671.1 E3 ubiquitin-protein ligase MSL2 isoform X1
XM_063265603.1 → XP_063121673.1 E3 ubiquitin-protein ligase MSL2 isoform X1
XM_063265604.1 → XP_063121674.1 E3 ubiquitin-protein ligase MSL2 isoform X1
XM_063265598.1 → XP_063121668.1 E3 ubiquitin-protein ligase MSL2 isoform X1
XM_063265599.1 → XP_063121669.1 E3 ubiquitin-protein ligase MSL2 isoform X1
XM_063265602.1 → XP_063121672.1 E3 ubiquitin-protein ligase MSL2 isoform X1
XM_039082585.2 → XP_038938513.1 E3 ubiquitin-protein ligase MSL2 isoform X3

UniProtKB/TrEMBL

A0A8I6AT15

Related

ENSRNOP00000097482.1, ENSRNOT00000108984.2

Conserved Domains (3) summary

TIGR03551
Location:170 → 212

F420_cofH; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit

pfam16682
Location:381 → 435

MSL2-CXC; CXC domain of E3 ubiquitin-protein ligase MSL2

cl17238
Location:1 → 37

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain