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    Dip2b disco-interacting protein 2 homolog B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300231, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dip2bprovided by RGD
    Official Full Name
    disco-interacting protein 2 homolog Bprovided by RGD
    Primary source
    RGD:1305671
    See related
    EnsemblRapid:ENSRNOG00000056106 AllianceGenome:RGD:1305671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305671
    Summary
    Predicted to enable alpha-tubulin binding activity. Predicted to be involved in negative regulation of axon extension and positive regulation of peptidyl-lysine acetylation. Predicted to be located in several cellular components, including axon; dendrite; and perikaryon. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human DIP2B (disco interacting protein 2 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 162.6), Lung (RPKM 154.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dip2b in Genome Data Viewer
    Location:
    7q36
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133053393..133231430)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131174575..131350417)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (141702034..141878945)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549417 Neighboring gene family with sequence similarity 186 member A Neighboring gene La ribonucleoprotein 4 Neighboring gene uncharacterized LOC134479576 Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 1, pseudogene 1 Neighboring gene uncharacterized LOC134479575 Neighboring gene activating transcription factor 1 Neighboring gene transmembrane serine protease 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a novel luciferase-like protein in the human female reproductive tract. Khorram O, et al. J Clin Endocrinol Metab, 2004 Nov. PMID 15531550
    2. CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1. Winnepenninckx B, et al. Am J Hum Genet, 2007 Feb. PMID 17236128, Free PMC Article
    3. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    disco-interacting protein 2 homolog B
    Names
    DIP2 disco-interacting protein 2 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432590.1 → NP_001419519.1  disco-interacting protein 2 homolog B isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2JY22, A6KCI1

    2. NM_001432591.1 → NP_001419520.1  disco-interacting protein 2 homolog B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6KCI1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      133053393..133231430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080376.2 → XP_038936304.1  disco-interacting protein 2 homolog B isoform X6

      Conserved Domains (2) summary
      cd05905
      Location:353 → 843
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:14 → 130
      DMAP_binding; DMAP1-binding Domain

    2. XM_063264367.1 → XP_063120437.1  disco-interacting protein 2 homolog B isoform X7

    3. XM_017595330.3 → XP_017450819.1  disco-interacting protein 2 homolog B isoform X1

      Related
      ENSRNOP00000070489.2, ENSRNOT00000086577.3

    4. XM_017595331.3 → XP_017450820.1  disco-interacting protein 2 homolog B isoform X2

      Related
      ENSRNOP00000111222.1, ENSRNOT00000136238.1

    5. XM_039080373.2 → XP_038936301.1  disco-interacting protein 2 homolog B isoform X3

      UniProtKB/TrEMBL
      A6KCI1
      Conserved Domains (2) summary
      cd05905
      Location:955 → 1520
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:14 → 130
      DMAP_binding; DMAP1-binding Domain

    6. XM_039080374.2 → XP_038936302.1  disco-interacting protein 2 homolog B isoform X4

      UniProtKB/TrEMBL
      A0A8I6ABD0, A6KCI1
      Related
      ENSRNOP00000089928.1, ENSRNOT00000118085.2
      Conserved Domains (2) summary
      cd05905
      Location:954 → 1519
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:14 → 130
      DMAP_binding; DMAP1-binding Domain

    7. XM_039080375.2 → XP_038936303.1  disco-interacting protein 2 homolog B isoform X5

      UniProtKB/TrEMBL
      A0A8I6ARX7, A6KCI1
      Related
      ENSRNOP00000095682.1, ENSRNOT00000106132.2
      Conserved Domains (2) summary
      cd05905
      Location:934 → 1499
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:14 → 130
      DMAP_binding; DMAP1-binding Domain

    RNA

    1. XR_005487417.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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