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    Pick1 protein interacting with PRKCA 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84591, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pick1provided by RGD
    Official Full Name
    protein interacting with PRKCA 1provided by RGD
    Primary source
    RGD:69437
    See related
    EnsemblRapid:ENSRNOG00000011507 AllianceGenome:RGD:69437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prkcabp
    Summary
    Enables several functions, including Arp2/3 complex binding activity; SNAP receptor activity; and glutamate receptor binding activity. Involved in several processes, including dendritic spine maintenance; long-term synaptic depression; and regulation of receptor internalization. Located in dendritic spine; perinuclear region of cytoplasm; and postsynaptic density. Part of protein-containing complex. Is active in several cellular components, including glutamatergic synapse; postsynaptic endocytic zone; and synaptic vesicle. Orthologous to human PICK1 (protein interacting with PRKCA 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 80.2), Brain (RPKM 65.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pick1 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112676890..112697275)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110796623..110816850)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120465472..120484824)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093688 Neighboring gene SRY-box transcription factor 10 Neighboring gene uncharacterized LOC134479937 Neighboring gene solute carrier family 16 member 8 Neighboring gene BAR/IMD domain containing adaptor protein 2 like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 29
    Function Evidence Code Pubs
    enables Arp2/3 complex binding PubMed 
    enables G protein-coupled glutamate receptor binding PubMed 
    enables G protein-coupled glutamate receptor binding PubMed 
    enables G protein-coupled receptor binding PubMed 
    enables GTPase binding PubMed 
    enables SNAP receptor activity PubMed 
    enables actin binding  
    enables actin filament binding PubMed 
    enables cytoskeletal protein binding PubMed 
    enables ephrin receptor binding PubMed 
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables ionotropic glutamate receptor binding PubMed 
    enables membrane curvature sensor activity  
    enables membrane curvature sensor activity  
    enables metal ion binding  
    enables phospholipid binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein domain specific binding PubMed 
    enables protein kinase C binding  
    enables protein kinase C binding PubMed 
    enables protein kinase C binding  
    enables protein kinase C binding  
    enables receptor tyrosine kinase binding PubMed 
    enables signaling receptor binding  
    enables signaling receptor binding  
    Items 1 - 25 of 29
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    involved_in cellular response to decreased oxygen levels PubMed 
    involved_in cellular response to glucose starvation PubMed 
    involved_in dendritic spine maintenance  
    involved_in dendritic spine maintenance PubMed 
    involved_in dendritic spine organization PubMed 
    involved_in dopamine transport PubMed 
    involved_in glial cell development PubMed 
    involved_in intracellular protein transport  
    involved_in long-term synaptic depression PubMed 
    involved_in membrane fusion  
    involved_in monoamine transport  
    involved_in monoamine transport  
    involved_in monoamine transport  
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation PubMed 
    involved_in negative regulation of gene expression PubMed 
    involved_in positive regulation of receptor internalization  
    involved_in positive regulation of receptor internalization PubMed 
    involved_in protein phosphorylation PubMed 
    acts_upstream_of_or_within protein targeting  
    involved_in receptor clustering  
    involved_in receptor clustering PubMed 
    involved_in receptor clustering  
    involved_in receptor clustering  
    involved_in regulation of Arp2/3 complex-mediated actin nucleation  
    involved_in regulation of insulin secretion  
    involved_in regulation of insulin secretion  
    involved_in regulation of kainate selective glutamate receptor activity PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    Items 1 - 25 of 30
    Items 1 - 20 of 41
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    located_in dendritic spine PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in mitochondrion  
    is_active_in neuron projection  
    located_in neuron projection PubMed 
    located_in neuron projection  
    located_in perinuclear region of cytoplasm PubMed 
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic density  
    located_in postsynaptic density PubMed 
    located_in postsynaptic density  
    located_in postsynaptic density  
    is_active_in postsynaptic early endosome  
    is_active_in postsynaptic endocytic zone PubMed 
    is_active_in postsynaptic endocytic zone PubMed 
    is_active_in postsynaptic specialization PubMed 
    located_in presynaptic membrane  
    located_in presynaptic membrane  
    located_in presynaptic membrane  
    part_of protein-containing complex PubMed 
    located_in synapse PubMed 
    located_in synapse  
    located_in synapse  
    is_active_in synaptic vesicle  
    is_active_in synaptic vesicle PubMed 
    is_active_in trans-Golgi network membrane  
    Items 1 - 20 of 41

    General protein information

    Preferred Names
    PRKCA-binding protein
    Names
    protein interacting with C kinase 1
    protein kinase C-alpha-binding protein
    protein that interacts with C kinase 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053460.2NP_445912.2  PRKCA-binding protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q546X4, Q925D1, Q9EP80
      UniProtKB/TrEMBL
      A6HSQ5, A6HSQ7, Q6GQQ2
      Conserved Domains (2) summary
      cd07659
      Location:146360
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
      smart00228
      Location:1999
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112676890..112697275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079986.2XP_038935914.1  PRKCA-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q546X4, Q925D1, Q9EP80
      UniProtKB/TrEMBL
      A6HSQ5, A6HSQ7, Q6GQQ2
      Related
      ENSRNOP00000016077.3, ENSRNOT00000016077.8
      Conserved Domains (2) summary
      cd07659
      Location:146360
      BAR_PICK1; The Bin/Amphiphysin/Rvs (BAR) domain of Protein Interacting with C Kinase 1
      smart00228
      Location:1999
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    2. XM_063264344.1XP_063120414.1  PRKCA-binding protein isoform X2

      UniProtKB/TrEMBL
      A6HSQ8
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