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    Pmch pro-melanin-concentrating hormone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24659, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pmchprovided by RGD
    Official Full Name
    pro-melanin-concentrating hormoneprovided by RGD
    Primary source
    RGD:3358
    See related
    EnsemblRapid:ENSRNOG00000066777 AllianceGenome:RGD:3358
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables type 1 melanin-concentrating hormone receptor binding activity. Involved in several processes, including lactation; modulation of chemical synaptic transmission; and positive regulation of circadian sleep/wake cycle, REM sleep. Located in extracellular space. Biomarker of obesity and sleeping sickness. Orthologous to several human genes including PMCH (pro-melanin concentrating hormone). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 183.5), Thymus (RPKM 44.2) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Pmch in Genome Data Viewer
    Location:
    7q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (24399404..24400720)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (22511934..22513250)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (28655206..28656522)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor 1 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma, pseudogene 6 Neighboring gene PARP1 binding protein Neighboring gene nucleoporin 37 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene uncharacterized LOC120093767

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in chemical synaptic transmission  
    involved_in drinking behavior PubMed 
    involved_in feeding behavior PubMed 
    involved_in feeding behavior  
    involved_in feeding behavior  
    involved_in feeding behavior  
    involved_in lactation PubMed 
    involved_in learning or memory PubMed 
    involved_in negative regulation of blood pressure PubMed 
    involved_in negative regulation of synaptic transmission, dopaminergic  
    involved_in negative regulation of synaptic transmission, dopaminergic PubMed 
    involved_in neuropeptide signaling pathway  
    involved_in positive regulation of circadian sleep/wake cycle, REM sleep PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    involved_in regulation of heart rate PubMed 
    involved_in regulation of neuronal synaptic plasticity PubMed 
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in extracellular space PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in synapse  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012625.2NP_036757.2  pro-MCH precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      P14200
      UniProtKB/TrEMBL
      A0A8I6ABX9, A6IFM9
      Related
      ENSRNOP00000091581.1, ENSRNOT00000095213.2
      Conserved Domains (1) summary
      pfam05824
      Location:83165
      Pro-MCH; Pro-melanin-concentrating hormone (Pro-MCH)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      24399404..24400720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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