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    Saxo4 stabilizer of axonemal microtubules 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252958, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Saxo4provided by RGD
    Official Full Name
    stabilizer of axonemal microtubules 4provided by RGD
    Primary source
    RGD:708532
    See related
    EnsemblRapid:ENSRNOG00000020620 AllianceGenome:RGD:708532
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Iiig9; Ppp1r32
    Summary
    Predicted to enable phosphatase binding activity. Predicted to be involved in flagellated sperm motility. Located in cilium and cytoplasm. Orthologous to human SAXO4 (stabilizer of axonemal microtubules 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 260.0) and Lung (RPKM 18.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Saxo4 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216538735..216548195, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207113807..207122378, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226518405..226527903, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483971 Neighboring gene leucine rich repeat containing 10B Neighboring gene succinate dehydrogenase complex assembly factor 2 Neighboring gene cleavage and polyadenylation specific factor 7 Neighboring gene transmembrane protein 216

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment. Baeza V, et al. Sci Rep, 2021 Sep 17. PMID 34535732, Free PMC Article
    2. Expression of a Novel Ciliary Protein, IIIG9, During the Differentiation and Maturation of Ependymal Cells. Cifuentes M, et al. Mol Neurobiol, 2018 Feb. PMID 28194645
    3. A novel mRNA expressed along brain ventricles. Danielson PE, et al. Brain Res Gene Expr Patterns, 2002 Jan. PMID 15018803
    4. Docking motif-guided mapping of the interactome of protein phosphatase-1. Hendrickx A, et al. Chem Biol, 2009 Apr 24. PMID 19389623
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment.
      Title: IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment.
    2. IIIG9 is localized in the cilia of adult ependymal cells and that its expression is correlated with the process of ependymal differentiation and with the maturation of radial glia.
      Title: Expression of a Novel Ciliary Protein, IIIG9, During the Differentiation and Maturation of Ependymal Cells.
    3. IIIG9 mRNA is expressed along brain ventricles
      Title: A novel mRNA expressed along brain ventricles.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93144

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axonemal A tubule inner sheath ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    stabilizer of axonemal microtubules 4
    Names
    protein phosphatase 1, regulatory subunit 32
    uncharacterized protein C11orf66 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145786.1 → NP_665729.1  stabilizer of axonemal microtubules 4

      See identical proteins and their annotated locations for NP_665729.1

      Status: PROVISIONAL

      Source sequence(s)
      AY032665
      UniProtKB/Swiss-Prot
      Q66HR9, Q91XJ3, Q91XJ4
      UniProtKB/TrEMBL
      A6I033
      Related
      ENSRNOP00000028003.2, ENSRNOT00000028003.5
      Conserved Domains (1) summary
      pfam15691
      Location:2 → 416
      PPP1R32; Protein phosphatase 1 regulatory subunit 32

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      216538735..216548195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281660.1 → XP_063137730.1  stabilizer of axonemal microtubules 4 isoform X1

      UniProtKB/Swiss-Prot
      Q66HR9, Q91XJ3, Q91XJ4
      UniProtKB/TrEMBL
      A6I033, A6I034

    2. XM_006231016.5 → XP_006231078.1  stabilizer of axonemal microtubules 4 isoform X1

      See identical proteins and their annotated locations for XP_006231078.1

      UniProtKB/Swiss-Prot
      Q66HR9, Q91XJ3, Q91XJ4
      UniProtKB/TrEMBL
      A6I033, A6I034
      Conserved Domains (1) summary
      pfam15691
      Location:1 → 372
      PPP1R32; Protein phosphatase 1 regulatory subunit 32
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HR9.1 GenPept UniProtKB/Swiss-Prot:Q66HR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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