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    Ank2 ankyrin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362036, updated on 9-Dec-2024

    Summary

    Symbol
    Ank2provided by RGD
    Full Name
    ankyrin 2provided by RGD
    Primary source
    RGD:620156
    See related
    EnsemblRapid:ENSRNOG00000011076 AllianceGenome:RGD:620156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ank3
    Summary
    Enables protein kinase binding activity and transmembrane transporter binding activity. A structural constituent of cytoskeleton. Involved in paranodal junction assembly and response to methylmercury. Predicted to be located in several cellular components, including T-tubule; basolateral plasma membrane; and myofibril. Predicted to be active in paranodal junction. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in ankyrin-B-related cardiac arrhythmia; atrial fibrillation; long QT syndrome; and sick sinus syndrome. Orthologous to human ANK2 (ankyrin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 503.8), Heart (RPKM 95.2) and 4 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ank2 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    58
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (218052555..218628414, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (215378028..215954015, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (231224643..231522655, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene histidine triad nucleotide binding protein 1, pseudogene 2 Neighboring gene calcium/calmodulin-dependent protein kinase II delta Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120101096 Neighboring gene uncharacterized LOC120101097 Neighboring gene uncharacterized LOC134485962 Neighboring gene adenosylhomocysteinase-like Neighboring gene transfer RNA valine (anticodon AAC) 18 Neighboring gene uncharacterized LOC120101095 Neighboring gene La ribonucleoprotein 7, transcriptional regulator Neighboring gene zinc finger, GRF-type containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding  
    enables enzyme binding  
    enables phosphorylation-dependent protein binding  
    enables potassium channel regulator activity  
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables protein kinase binding  
    enables protein-macromolecule adaptor activity  
    enables spectrin binding  
    enables structural constituent of cytoskeleton PubMed 
    enables transmembrane transporter binding PubMed 
    enables transmembrane transporter binding  
    Items 1 - 25 of 45
    Process Evidence Code Pubs
    involved_in SA node cell action potential  
    involved_in SA node cell to atrial cardiac muscle cell communication  
    acts_upstream_of_or_within T-tubule organization  
    involved_in T-tubule organization  
    involved_in atrial cardiac muscle cell action potential  
    involved_in atrial cardiac muscle cell to AV node cell communication  
    involved_in atrial septum development  
    acts_upstream_of_or_within cardiac muscle contraction  
    involved_in cytoskeleton organization  
    involved_in intracellular calcium ion homeostasis  
    involved_in nervous system development PubMed 
    involved_in paranodal junction assembly PubMed 
    involved_in positive regulation of calcium ion transmembrane transporter activity  
    involved_in positive regulation of calcium ion transport  
    involved_in positive regulation of cation channel activity  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of potassium ion transmembrane transporter activity  
    involved_in positive regulation of potassium ion transport  
    acts_upstream_of_or_within protein localization  
    involved_in protein localization  
    involved_in protein localization to M-band  
    involved_in protein localization to T-tubule  
    involved_in protein localization to cell surface  
    involved_in protein localization to endoplasmic reticulum  
    involved_in protein localization to organelle  
    acts_upstream_of_or_within protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    involved_in protein stabilization  
    involved_in regulation of AV node cell action potential  
    involved_in regulation of SA node cell action potential  
    involved_in regulation of atrial cardiac muscle cell action potential  
    involved_in regulation of calcium ion transmembrane transporter activity  
    involved_in regulation of calcium ion transport  
    involved_in regulation of cardiac muscle cell contraction  
    acts_upstream_of_or_within regulation of cardiac muscle cell membrane potential  
    involved_in regulation of cardiac muscle contraction  
    involved_in regulation of cardiac muscle contraction by calcium ion signaling  
    involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  
    acts_upstream_of_or_within regulation of cation channel activity  
    involved_in regulation of heart rate  
    involved_in regulation of heart rate by cardiac conduction  
    involved_in regulation of release of sequestered calcium ion into cytosol  
    involved_in regulation of ventricular cardiac muscle cell membrane repolarization  
    involved_in response to methylmercury PubMed 
    involved_in ventricular cardiac muscle cell action potential  
    Items 1 - 25 of 45
    Component Evidence Code Pubs
    located_in A band  
    located_in M band  
    located_in T-tubule  
    located_in Z disc  
    located_in basolateral plasma membrane  
    located_in costamere  
    located_in cytoplasm  
    located_in cytoskeleton  
    is_active_in extrinsic component of cytoplasmic side of plasma membrane  
    located_in intercalated disc  
    is_active_in paranodal junction  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in postsynaptic density  
    located_in sarcolemma  

    General protein information

    Preferred Names
    ankyrin-2
    Names
    ankyrin 2, brain
    ankyrin 2, neuronal
    ankyrin 3, epithelial

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427159.1NP_001414088.1  ankyrin-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      Related
      ENSRNOP00000015386.10, ENSRNOT00000015386.11

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      218052555..218628414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282205.1XP_063138275.1  ankyrin-2 isoform X28

    2. XM_063282210.1XP_063138280.1  ankyrin-2 isoform X35

    3. XM_063282212.1XP_063138282.1  ankyrin-2 isoform X45

      Related
      ENSRNOP00000098357.2, ENSRNOT00000120732.2
    4. XM_063282199.1XP_063138269.1  ankyrin-2 isoform X21

      Related
      ENSRNOP00000052477.7, ENSRNOT00000055615.8
    5. XM_063282195.1XP_063138265.1  ankyrin-2 isoform X16

    6. XM_063282185.1XP_063138255.1  ankyrin-2 isoform X5

    7. XM_063282213.1XP_063138283.1  ankyrin-2 isoform X46

    8. XM_039104008.2XP_038959936.1  ankyrin-2 isoform X8

      Conserved Domains (9) summary
      smart00218
      Location:843980
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00121
      Location:14312195
      PTZ00121; MAEBL; Provisional
      PHA03095
      Location:261546
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:15801861
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08804
      Location:34363519
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:287318
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:618670
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12011330
      UPA_2; UPA domain
      cl39094
      Location:418642
      Ank_2; Ankyrin repeats (3 copies)
    9. XM_063282182.1XP_063138252.1  ankyrin-2 isoform X1

    10. XM_063282202.1XP_063138272.1  ankyrin-2 isoform X24

      UniProtKB/TrEMBL
      F1M9N9
    11. XM_063282198.1XP_063138268.1  ankyrin-2 isoform X19

      UniProtKB/TrEMBL
      F1M9N9
    12. XM_039104025.2XP_038959953.1  ankyrin-2 isoform X34

      Related
      ENSRNOP00000073918.3, ENSRNOT00000080470.3
      Conserved Domains (10) summary
      smart00218
      Location:798902
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00121
      Location:13532117
      PTZ00121; MAEBL; Provisional
      PHA03095
      Location:87392
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:15021783
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08804
      Location:33583441
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:593645
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:11231252
      UPA_2; UPA domain
      pfam12796
      Location:1130
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:342617
      Ank_2; Ankyrin repeats (3 copies)
    13. XM_063282192.1XP_063138262.1  ankyrin-2 isoform X13

    14. XM_039104019.2XP_038959947.1  ankyrin-2 isoform X20

      Conserved Domains (10) summary
      smart00218
      Location:831935
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00121
      Location:13862150
      PTZ00121; MAEBL; Provisional
      PHA03095
      Location:269554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:15351816
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08804
      Location:33913474
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:11561285
      UPA_2; UPA domain
      pfam12796
      Location:1130
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:426650
      Ank_2; Ankyrin repeats (3 copies)
    15. XM_063282193.1XP_063138263.1  ankyrin-2 isoform X14

      UniProtKB/TrEMBL
      F1M9N9
    16. XM_063282186.1XP_063138256.1  ankyrin-2 isoform X6

    17. XM_063282197.1XP_063138267.1  ankyrin-2 isoform X18

    18. XM_063282187.1XP_063138257.1  ankyrin-2 isoform X7

    19. XM_039103998.2XP_038959926.1  ankyrin-2 isoform X2

      Conserved Domains (10) summary
      smart00218
      Location:861998
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00121
      Location:14492213
      PTZ00121; MAEBL; Provisional
      PHA03095
      Location:269554
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:15981879
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08804
      Location:34543537
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:295326
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:626678
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12191348
      UPA_2; UPA domain
      pfam12796
      Location:1130
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:426650
      Ank_2; Ankyrin repeats (3 copies)
    20. XM_063282191.1XP_063138261.1  ankyrin-2 isoform X12

    21. XM_063282209.1XP_063138279.1  ankyrin-2 isoform X33

    22. XM_063282208.1XP_063138278.1  ankyrin-2 isoform X31

      UniProtKB/TrEMBL
      F1M9N9
    23. XM_063282189.1XP_063138259.1  ankyrin-2 isoform X10

    24. XM_063282206.1XP_063138276.1  ankyrin-2 isoform X29

    25. XM_063282184.1XP_063138254.1  ankyrin-2 isoform X4

    26. XM_063282204.1XP_063138274.1  ankyrin-2 isoform X26

      UniProtKB/TrEMBL
      F1M9N9
    27. XM_063282217.1XP_063138287.1  ankyrin-2 isoform X50

    28. XM_063282207.1XP_063138277.1  ankyrin-2 isoform X30

      UniProtKB/TrEMBL
      A0A0G2K6R9
    29. XM_039104045.2XP_038959973.1  ankyrin-2 isoform X43

      Conserved Domains (7) summary
      smart00218
      Location:9331037
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:14161499
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:728780
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12581387
      UPA_2; UPA domain
      pfam12796
      Location:402493
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:477752
      Ank_2; Ankyrin repeats (3 copies)
    30. XM_039104044.2XP_038959972.1  ankyrin-2 isoform X42

      Conserved Domains (7) summary
      smart00218
      Location:9451049
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08804
      Location:14281511
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:728780
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12701399
      UPA_2; UPA domain
      pfam12796
      Location:402493
      Ank_2; Ankyrin repeats (3 copies)
      cl39094
      Location:477752
      Ank_2; Ankyrin repeats (3 copies)
    31. XM_063282200.1XP_063138270.1  ankyrin-2 isoform X22

      UniProtKB/TrEMBL
      A0A0G2K6R9
    32. XM_039104042.2XP_038959970.1  ankyrin-2 isoform X41

      Conserved Domains (7) summary
      smart00218
      Location:9661070
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:404689
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:14491532
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:761813
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12911420
      UPA_2; UPA domain
      cl39094
      Location:561785
      Ank_2; Ankyrin repeats (3 copies)
    33. XM_039104040.2XP_038959968.1  ankyrin-2 isoform X40

      Conserved Domains (7) summary
      smart00218
      Location:9661070
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:404689
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:14491532
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:761813
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12911420
      UPA_2; UPA domain
      cl39094
      Location:561785
      Ank_2; Ankyrin repeats (3 copies)
    34. XM_039104023.2XP_038959951.1  ankyrin-2 isoform X32

      UniProtKB/TrEMBL
      A0A0G2K6R9
      Related
      ENSRNOP00000035307.7, ENSRNOT00000037255.8
      Conserved Domains (9) summary
      smart00218
      Location:9661070
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00121
      Location:15212285
      PTZ00121; MAEBL; Provisional
      PHA03095
      Location:404689
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:16701951
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08804
      Location:35263609
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:761813
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:12911420
      UPA_2; UPA domain
      cl39094
      Location:561785
      Ank_2; Ankyrin repeats (3 copies)
    35. XM_039104038.2XP_038959966.1  ankyrin-2 isoform X39

      Conserved Domains (7) summary
      smart00218
      Location:9661103
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:404689
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:14821565
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:761813
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13241453
      UPA_2; UPA domain
      cl39094
      Location:561785
      Ank_2; Ankyrin repeats (3 copies)
    36. XM_063282215.1XP_063138285.1  ankyrin-2 isoform X48

    37. XM_039104022.2XP_038959950.1  ankyrin-2 isoform X27

      UniProtKB/TrEMBL
      A0A0G2K6R9
      Conserved Domains (9) summary
      smart00218
      Location:9661103
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PTZ00121
      Location:15542318
      PTZ00121; MAEBL; Provisional
      PHA03095
      Location:404689
      PHA03095; ankyrin-like protein; Provisional
      PHA03307
      Location:17031984
      PHA03307; transcriptional regulator ICP4; Provisional
      cd08804
      Location:35593642
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:761813
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13241453
      UPA_2; UPA domain
      cl39094
      Location:561785
      Ank_2; Ankyrin repeats (3 copies)
    38. XM_039104031.2XP_038959959.1  ankyrin-2 isoform X37

      Conserved Domains (7) summary
      smart00218
      Location:9781115
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:404689
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:14941577
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:430461
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:761813
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13361465
      UPA_2; UPA domain
      cl39094
      Location:561785
      Ank_2; Ankyrin repeats (3 copies)
    39. XM_063282194.1XP_063138264.1  ankyrin-2 isoform X15

      UniProtKB/TrEMBL
      A0A0G2K6R9
    40. XM_063282188.1XP_063138258.1  ankyrin-2 isoform X9

      UniProtKB/TrEMBL
      A0A0G2K6R9
    41. XM_063282211.1XP_063138281.1  ankyrin-2 isoform X44

    42. XM_063282201.1XP_063138271.1  ankyrin-2 isoform X23

      UniProtKB/TrEMBL
      A0A0G2JZ56
    43. XM_063282203.1XP_063138273.1  ankyrin-2 isoform X25

      UniProtKB/TrEMBL
      A0A0G2KAS9
    44. XM_039104034.2XP_038959962.1  ankyrin-2 isoform X38

      Conserved Domains (7) summary
      smart00218
      Location:9811118
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:419704
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:14971580
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:776828
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13391468
      UPA_2; UPA domain
      cl39094
      Location:576800
      Ank_2; Ankyrin repeats (3 copies)
    45. XM_039104029.2XP_038959957.1  ankyrin-2 isoform X36

      Conserved Domains (7) summary
      smart00218
      Location:9811118
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA03095
      Location:419704
      PHA03095; ankyrin-like protein; Provisional
      cd08804
      Location:14971580
      Death_ank2; Death domain of Ankyrin-2
      sd00045
      Location:445476
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:776828
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13391468
      UPA_2; UPA domain
      cl39094
      Location:576800
      Ank_2; Ankyrin repeats (3 copies)
    46. XM_063282196.1XP_063138266.1  ankyrin-2 isoform X17

      UniProtKB/TrEMBL
      A0A0G2JZ56
      Related
      ENSRNOP00000075511.3, ENSRNOT00000084756.3
    47. XM_063282214.1XP_063138284.1  ankyrin-2 isoform X47

    48. XM_063282216.1XP_063138286.1  ankyrin-2 isoform X49

    49. XM_063282190.1XP_063138260.1  ankyrin-2 isoform X11

      UniProtKB/TrEMBL
      A0A0G2JZ56
    50. XM_063282183.1XP_063138253.1  ankyrin-2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JZ56
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