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    Acvr2a activin A receptor type 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29263, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acvr2aprovided by RGD
    Official Full Name
    activin A receptor type 2Aprovided by RGD
    Primary source
    RGD:70911
    See related
    EnsemblRapid:ENSRNOG00000065897 AllianceGenome:RGD:70911
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Acvr2; rActR-II
    Summary
    Enables activin binding activity and inhibin binding activity. Involved in several processes, including SMAD protein signal transduction; cellular response to oxygen-glucose deprivation; and positive regulation of follicle-stimulating hormone secretion. Predicted to be located in cell surface and cytoplasm. Predicted to be part of activin receptor complex and inhibin-betaglycan-ActRII complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Lynch syndrome and colon cancer. Orthologous to human ACVR2A (activin A receptor type 2A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 192.7), Brain (RPKM 161.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Acvr2a in Genome Data Viewer
    Location:
    3q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (53614143..53701933)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (33204961..33292673)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (32947901..33034598)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486360 Neighboring gene uncharacterized LOC108350372 Neighboring gene uncharacterized LOC134486282 Neighboring gene origin recognition complex, subunit 4 Neighboring gene methyl-CpG binding domain protein 5 Neighboring gene uncharacterized LOC120101434

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 35
    Function Evidence Code Pubs
    enables ATP binding  
    enables BMP receptor activity  
    enables BMP receptor activity  
    enables BMP receptor activity  
    enables PDZ domain binding  
    enables PDZ domain binding  
    enables activin binding PubMed 
    enables activin binding  
    contributes_to activin binding  
    enables activin binding  
    enables activin binding PubMed 
    enables activin receptor activity  
    contributes_to activin receptor activity  
    enables activin receptor activity  
    enables activin receptor activity  
    enables activin receptor activity, type I  
    enables activin receptor activity, type I  
    enables activin receptor activity, type II  
    enables activin receptor activity, type II  
    enables coreceptor activity  
    enables coreceptor activity  
    enables growth factor binding  
    enables growth factor binding  
    enables identical protein binding  
    enables identical protein binding  
    enables inhibin binding PubMed 
    enables inhibin binding  
    enables inhibin binding  
    enables metal ion binding  
    enables protein serine/threonine kinase activity  
    enables transforming growth factor beta receptor activity, type I  
    enables transforming growth factor beta receptor activity, type II  
    enables transforming growth factor beta receptor activity, type III  
    enables transmembrane receptor protein serine/threonine kinase activity  
    enables transmembrane receptor protein serine/threonine kinase activity PubMed 
    Items 1 - 25 of 35
    Items 1 - 25 of 55
    Process Evidence Code Pubs
    involved_in BMP signaling pathway  
    acts_upstream_of_or_within BMP signaling pathway  
    involved_in BMP signaling pathway  
    involved_in BMP signaling pathway  
    involved_in SMAD protein signal transduction PubMed 
    involved_in Sertoli cell proliferation  
    acts_upstream_of_or_within Sertoli cell proliferation  
    involved_in activin receptor signaling pathway  
    involved_in activin receptor signaling pathway  
    involved_in activin receptor signaling pathway  
    involved_in adrenal gland development PubMed 
    involved_in anterior/posterior pattern specification  
    acts_upstream_of_or_within anterior/posterior pattern specification  
    involved_in autophagy PubMed 
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway  
    involved_in cellular response to BMP stimulus  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to oxygen-glucose deprivation PubMed 
    involved_in determination of left/right symmetry  
    acts_upstream_of_or_within determination of left/right symmetry  
    involved_in embryonic skeletal system development  
    acts_upstream_of_or_within embryonic skeletal system development  
    involved_in gastrulation with mouth forming second  
    acts_upstream_of_or_within gastrulation with mouth forming second  
    acts_upstream_of_or_within male gonad development  
    involved_in mesoderm development  
    acts_upstream_of_or_within mesoderm development  
    involved_in odontogenesis of dentin-containing tooth  
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth  
    involved_in osteoblast differentiation  
    involved_in pattern specification process  
    involved_in penile erection  
    acts_upstream_of_or_within penile erection  
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of activin receptor signaling pathway  
    involved_in positive regulation of activin receptor signaling pathway  
    involved_in positive regulation of bone mineralization  
    involved_in positive regulation of bone mineralization  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of erythrocyte differentiation  
    involved_in positive regulation of follicle-stimulating hormone secretion PubMed 
    involved_in positive regulation of osteoblast differentiation  
    involved_in positive regulation of osteoblast differentiation  
    acts_upstream_of_or_within positive regulation of protein phosphorylation  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein phosphorylation PubMed 
    involved_in regulation of nitric oxide biosynthetic process  
    acts_upstream_of_or_within regulation of nitric oxide biosynthetic process  
    acts_upstream_of_or_within regulation of signal transduction  
    involved_in sperm ejaculation  
    acts_upstream_of_or_within sperm ejaculation  
    involved_in spermatogenesis  
    acts_upstream_of_or_within spermatogenesis  
    Items 1 - 25 of 55
    Component Evidence Code Pubs
    part_of activin receptor complex  
    located_in cell surface  
    located_in cell surface  
    located_in cytoplasm  
    located_in cytoplasm  
    part_of inhibin-betaglycan-ActRII complex  
    part_of inhibin-betaglycan-ActRII complex  
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in plasma membrane  
    is_active_in plasma membrane  
    part_of receptor complex  
    part_of receptor complex  

    General protein information

    Preferred Names
    activin receptor type-2A
    Names
    ACTR-IIA
    activin A receptor, type IIA
    activin receptor IIA
    activin receptor type IIA
    type II activin receptor
    NP_113759.2
    XP_063139269.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031571.3NP_113759.2  activin receptor type-2A precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P38444
      UniProtKB/TrEMBL
      A6JEZ1
      Related
      ENSRNOP00000083010.2, ENSRNOT00000113342.2
      Conserved Domains (2) summary
      cd14141
      Location:196485
      STKc_ACVR2a; Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor
      pfam01064
      Location:59114
      Activin_recp; Activin types I and II receptor domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      53614143..53701933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283199.1XP_063139269.1  activin receptor type-2A isoform X1

      UniProtKB/Swiss-Prot
      P38444
      UniProtKB/TrEMBL
      F1MA24
      Related
      ENSRNOP00000007404.5, ENSRNOT00000007404.9
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