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    Rlbp1 retinaldehyde binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293049, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rlbp1provided by RGD
    Official Full Name
    retinaldehyde binding protein 1provided by RGD
    Primary source
    RGD:1309649
    See related
    EnsemblRapid:ENSRNOG00000016897 AllianceGenome:RGD:1309649
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 11-cis retinal binding activity and phosphatidylinositol bisphosphate binding activity. Located in cell body. Human ortholog(s) of this gene implicated in Bothnia retinal dystrophy; Newfoundland cone-rod dystrophy; fundus albipunctatus; night blindness; and retinitis pigmentosa. Orthologous to human RLBP1 (retinaldehyde binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 83.0) See more
    Orthologs
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    Genomic context

    See Rlbp1 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (142718262..142731621, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (133308920..133322296, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (141097789..141111375, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene abhydrolase domain containing 2, acylglycerol lipase Neighboring gene uncharacterized LOC134483740 Neighboring gene FA complementation group I Neighboring gene transfer RNA arginine (anticodon UCG) 1 Neighboring gene DNA polymerase gamma, catalytic subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 11-cis retinal binding  
    enables phosphatidylinositol bisphosphate binding  
    Component Evidence Code Pubs
    located_in cell body PubMed 
    located_in centrosome  
    located_in centrosome  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    retinaldehyde-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106274.2 → NP_001099744.1  retinaldehyde-binding protein 1

      See identical proteins and their annotated locations for NP_001099744.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JC48, D3Z956
      Related
      ENSRNOP00000022962.5, ENSRNOT00000022962.8
      Conserved Domains (2) summary
      smart01100
      Location:60 → 117
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam00650
      Location:143 → 292
      CRAL_TRIO; CRAL/TRIO domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      142718262..142731621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105632.2 → XP_038961560.1  retinaldehyde-binding protein 1 isoform X1

      Conserved Domains (1) summary
      pfam00650
      Location:11 → 160
      CRAL_TRIO; CRAL/TRIO domain
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