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    Mapk9 mitogen-activated protein kinase 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 50658, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mapk9provided by RGD
    Official Full Name
    mitogen-activated protein kinase 9provided by RGD
    Primary source
    RGD:628847
    See related
    EnsemblRapid:ENSRNOG00000002823 AllianceGenome:RGD:628847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SAPK
    Summary
    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases are multifunctional proteins. They are involved in a wide variety of cellular processes such as growth, proliferation, differentiation, transcription regulation, and development. They function in stress responses, apoptosis, inflammation and transformation. For example, this kinase plays a dominant role in mediating proliferation of lung cancer and prostate cancer cells, and in regulation of osmotic stress-induced tight junction disruption. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2012]
    Expression
    Biased expression in Brain (RPKM 297.8), Liver (RPKM 173.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Mapk9 in Genome Data Viewer
    Location:
    10q21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (34670750..34711972)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34169661..34211138)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35333859..35374364)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095087 Neighboring gene uncharacterized LOC120095088 Neighboring gene glutamine-fructose-6-phosphate transaminase 2 Neighboring gene uncharacterized LOC120095089 Neighboring gene microRNA 336 Neighboring gene RasGEF domain family, member 1C Neighboring gene ring finger protein 130 Neighboring gene microRNA 340-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding PubMed 
    enables ATP binding  
    enables JUN kinase activity  
    enables JUN kinase activity PubMed 
    enables JUN kinase activity  
    enables JUN kinase activity PubMed 
    enables JUN kinase activity  
    enables mitogen-activated protein kinase kinase kinase binding PubMed 
    enables protein binding PubMed 
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine/tyrosine kinase activity  
    enables protein serine/threonine/tyrosine kinase activity  
    Items 1 - 25 of 64
    Process Evidence Code Pubs
    involved_in JNK cascade  
    involved_in JNK cascade PubMed 
    involved_in JNK cascade  
    involved_in JNK cascade  
    involved_in JUN phosphorylation PubMed 
    involved_in apoptotic signaling pathway  
    acts_upstream_of apoptotic signaling pathway  
    involved_in cellular hyperosmotic response PubMed 
    involved_in cellular response to UV PubMed 
    involved_in cellular response to amyloid-beta PubMed 
    involved_in cellular response to growth factor stimulus PubMed 
    involved_in cellular response to interleukin-1 PubMed 
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in cellular response to reactive oxygen species  
    involved_in cellular response to reactive oxygen species  
    involved_in cellular response to tumor necrosis factor PubMed 
    involved_in extrinsic apoptotic signaling pathway PubMed 
    involved_in inflammatory response to wounding  
    involved_in inflammatory response to wounding  
    involved_in modulation of chemical synaptic transmission  
    involved_in modulation of chemical synaptic transmission  
    involved_in neuron development PubMed 
    involved_in neuron projection development PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of apoptotic signaling pathway  
    acts_upstream_of_or_within positive regulation of apoptotic signaling pathway  
    involved_in positive regulation of cell differentiation PubMed 
    involved_in positive regulation of chemokine production PubMed 
    involved_in positive regulation of cytokine production involved in inflammatory response  
    involved_in positive regulation of cytokine production involved in inflammatory response  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of macrophage derived foam cell differentiation  
    involved_in positive regulation of macrophage derived foam cell differentiation  
    involved_in positive regulation of podosome assembly  
    acts_upstream_of_or_within positive regulation of podosome assembly  
    involved_in positive regulation of prostaglandin biosynthetic process PubMed 
    involved_in positive regulation of prostaglandin secretion PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of protein ubiquitination  
    involved_in positive regulation of protein ubiquitination  
    involved_in protein localization to tricellular tight junction  
    acts_upstream_of_or_within protein localization to tricellular tight junction  
    involved_in protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in protein targeting to mitochondrion PubMed 
    involved_in regulation of JNK cascade PubMed 
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of protein ubiquitination PubMed 
    involved_in release of cytochrome c from mitochondria PubMed 
    involved_in response to amine PubMed 
    involved_in response to cadmium ion  
    acts_upstream_of_or_within response to cadmium ion  
    involved_in response to mechanical stimulus PubMed 
    involved_in response to nerve growth factor PubMed 
    involved_in response to tetrachloromethane PubMed 
    involved_in response to toxic substance PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in rhythmic process  
    Items 1 - 25 of 64
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse  
    is_active_in Schaffer collateral - CA1 synapse  
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nuclear speck  
    located_in nuclear speck  
    is_active_in nucleus  
    located_in perikaryon PubMed 
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    mitogen-activated protein kinase 9
    Names
    MAP kinase 9
    MAPK 9
    SAPK-alpha
    c-Jun N-terminal kinase 2
    p54-alpha
    stress activated protein kinase alpha II
    stress-activated protein kinase JNK2
    NP_001257473.1
    NP_001257474.1
    NP_059018.1
    XP_006246380.1
    XP_017452968.1
    XP_038942586.1
    XP_038942587.1
    XP_063125748.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270544.1NP_001257473.1  mitogen-activated protein kinase 9 isoform 2

      See identical proteins and their annotated locations for NP_001257473.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate exon in the coding region, compared to variant 1. The resulting isoform (2) is of the same size, but has a different internal segment, compared to isoform 1.
      Source sequence(s)
      BC061870, BI282175, DN948189, JAXUCZ010000010, L27111
      UniProtKB/TrEMBL
      A0A0G2JYS4, A6HDY2
      Related
      ENSRNOP00000070771.2, ENSRNOT00000083688.3
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    2. NM_001270545.1NP_001257474.1  mitogen-activated protein kinase 9 isoform 3

      See identical proteins and their annotated locations for NP_001257474.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is the longer transcript and has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC061870, BI282175, DN948189, JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A503, Q6P727
      Related
      ENSRNOP00000003987.3, ENSRNOT00000003987.7
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    3. NM_017322.2NP_059018.1  mitogen-activated protein kinase 9 isoform 1

      See identical proteins and their annotated locations for NP_059018.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC061870, BI282175, DN948189, JAXUCZ010000010, L27112
      UniProtKB/Swiss-Prot
      P49186
      UniProtKB/TrEMBL
      A0A0G2JYS4, A6HDY4
      Conserved Domains (1) summary
      cd07850
      Location:25360
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      34670750..34711972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269678.1XP_063125748.1  mitogen-activated protein kinase 9 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYS4, D4A5V8
    2. XM_017597479.3XP_017452968.1  mitogen-activated protein kinase 9 isoform X5

      UniProtKB/TrEMBL
      A6HDY6
      Conserved Domains (1) summary
      cl21453
      Location:25210
      PKc_like; Protein Kinases, catalytic domain
    3. XM_039086658.2XP_038942586.1  mitogen-activated protein kinase 9 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A503
      Related
      ENSRNOP00000090510.2, ENSRNOT00000107644.2
      Conserved Domains (1) summary
      cd07850
      Location:16334
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    4. XM_006246318.5XP_006246380.1  mitogen-activated protein kinase 9 isoform X1

      See identical proteins and their annotated locations for XP_006246380.1

      UniProtKB/TrEMBL
      A0A8I6A503, A0A8I6AND2
      Related
      ENSRNOP00000087042.1, ENSRNOT00000116124.2
      Conserved Domains (1) summary
      cd07850
      Location:16334
      STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
    5. XM_039086659.2XP_038942587.1  mitogen-activated protein kinase 9 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:1240
      PKc_like; Protein Kinases, catalytic domain
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