Wnt9a Wnt family member 9A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wnt9aprovided by RGD
Official Full Name: Wnt family member 9Aprovided by RGD
Primary source: RGD:1305018
See related: EnsemblRapid:ENSRNOG00000003066 AllianceGenome:RGD:1305018
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable receptor ligand activity. Predicted to be involved in negative regulation of cell population proliferation. Predicted to act upstream of or within several processes, including embryonic morphogenesis; negative regulation of chondrocyte differentiation; and positive regulation of smoothened signaling pathway. Predicted to be located in extracellular region. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human WNT9A (Wnt family member 9A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 23.2), Lung (RPKM 9.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (44593691..44620682)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (44094140..44121134)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (45659045..45686103)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of downregulation of Mig-6, Wnt-7b, and Wnt-9a during osteoarthritis; Wnt-7b is expressed also in osteoblast-like cells
Title: Expression of MIG-6, WNT-9A, and WNT-7B during osteoarthritis.
5'-flanking promoter region was significantly divergent between human WNT9A and rodent Wnt9a cancer genes.
Title: Comparative genomics on Wnt9a orthologs.

Submit: New GeneRIF Correction

General gene information

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Markers

Wnt9a (e-PCR), detects polymorphism
- UniSTS:471333

Wnt14 (e-PCR), detects polymorphism
- UniSTS:254324

Wnt9a (e-PCR), detects polymorphism
- UniSTS:507327

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cartilage development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-9a

Names: wingless related MMTV integration site 9A; wingless-type MMTV integration site 9A; wingless-type MMTV integration site family, member 9A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105783.2 → NP_001099253.2 protein Wnt-9a precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

D3ZF63

Related

ENSRNOP00000055129.4, ENSRNOT00000058327.5

Conserved Domains (1) summary

cl38924
Location:64 → 364

Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family