U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Adam33 ADAM metallopeptidase domain 33 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311425, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Adam33provided by RGD
    Official Full Name
    ADAM metallopeptidase domain 33provided by RGD
    Primary source
    RGD:1305278
    See related
    EnsemblRapid:ENSRNOG00000021242 AllianceGenome:RGD:1305278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and rhinitis. Orthologous to human ADAM33 (ADAM metallopeptidase domain 33). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 78.4), Lung (RPKM 77.4) and 7 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Adam33 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138715428..138736392, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118262395..118283456, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123595018..123607549, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene attractin Neighboring gene uncharacterized LOC134486154 Neighboring gene GDNF family receptor alpha 4 Neighboring gene sialic acid binding Ig like lectin 1 Neighboring gene uncharacterized LOC120101662

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Overexpression of soluble ADAM33 promotes a hypercontractile phenotype of the airway smooth muscle cell in rat. Duan Y, et al. Exp Cell Res, 2016 Nov 15. PMID 27720670
    2. ADAM33 protein expression and the mechanics of airway smooth muscle cells are highly correlated in ovalbumin-sensitized rats. Lin F, et al. Mol Med Rep, 2013 Oct. PMID 23934418
    3. ADAM33 gene polymorphisms in chronic obstructive pulmonary disease. Pabst S, et al. Eur J Med Res, 2009 Dec 7. PMID 20156753, Free PMC Article
    4. Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population. Wang X, et al. BMC Med Genet, 2009 Dec 10. PMID 20003279, Free PMC Article
    5. A Six-SNP haplotype of ADAM33 is associated with asthma in a population of Cartagena, Colombia. Vergara CI, et al. Int Arch Allergy Immunol, 2010. PMID 19940503, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. soluble ADAM33 overexpression altered the mechanical behaviors of airway smooth muscle cells.
      Title: Overexpression of soluble ADAM33 promotes a hypercontractile phenotype of the airway smooth muscle cell in rat.
    2. ADAM33 is a mediator of airway smooth muscle cell dysfunction in asthma.
      Title: ADAM33 protein expression and the mechanics of airway smooth muscle cells are highly correlated in ovalbumin-sensitized rats.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 33
    Names
    a disintegrin and metallopeptidase domain 33
    a disintegrin and metalloprotease domain 33

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395113.1 → NP_001382042.1  disintegrin and metalloproteinase domain-containing protein 33 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      F1M8J6
      Related
      ENSRNOP00000040646.6, ENSRNOT00000051404.8
      Conserved Domains (4) summary
      smart00050
      Location:429 → 503
      DISIN; Homologues of snake disintegrins
      smart00608
      Location:505 → 647
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:213 → 410
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam01562
      Location:41 → 170
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138715428..138736392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_005501878.2 RNA Sequence

    2. XR_005501877.2 RNA Sequence

    3. XR_005501876.2 RNA Sequence

    4. XR_005501879.2 RNA Sequence

    5. XR_005501875.2 RNA Sequence

    6. XR_005501880.2 RNA Sequence

    7. XR_005501881.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107776.2: Suppressed sequence

      Description
      NM_001107776.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools