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    Adam11 ADAM metallopeptidase domain 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adam11provided by RGD
    Official Full Name
    ADAM metallopeptidase domain 11provided by RGD
    Primary source
    RGD:1307515
    See related
    EnsemblRapid:ENSRNOG00000002753 AllianceGenome:RGD:1307515
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in behavioral response to chemical pain; establishment of protein localization; and proteolysis. Predicted to be located in membrane. Orthologous to human ADAM11 (ADAM metallopeptidase domain 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 118.0), Muscle (RPKM 22.8) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adam11 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (88224185..88242865)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87724115..87742773)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (90731260..90749221)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095185 Neighboring gene uncharacterized LOC103693436 Neighboring gene DBF4B-CDC7 kinase regulatory subunit Neighboring gene gap junction protein, gamma 1 Neighboring gene HIG1 hypoxia inducible domain family, member 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in behavioral response to acetic acid induced pain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in behavioral response to formalin induced pain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in multicellular organismal response to stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 11
    Names
    a disintegrin and metallopeptidase domain 11
    a disintegrin and metalloprotease domain 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108300.1 → NP_001101770.1  disintegrin and metalloproteinase domain-containing protein 11

      See identical proteins and their annotated locations for NP_001101770.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HJM3, A6HJM4
      Conserved Domains (5) summary
      smart00608
      Location:495 → 633
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:204 → 401
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:418 → 492
      Disintegrin; Disintegrin
      pfam01421
      Location:204 → 403
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:41 → 153
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      88224185..88242865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247379.5 → XP_006247441.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X3

      UniProtKB/TrEMBL
      A6HJM3
      Conserved Domains (6) summary
      smart00608
      Location:534 → 672
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:243 → 440
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:457 → 531
      Disintegrin; Disintegrin
      pfam01421
      Location:243 → 442
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:80 → 192
      Pep_M12B_propep; Reprolysin family propeptide
      pfam07974
      Location:681 → 713
      EGF_2; EGF-like domain

    2. XM_017597402.3 → XP_017452891.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X1

      UniProtKB/TrEMBL
      A6HJM3
      Related
      ENSRNOP00000061628.4, ENSRNOT00000064429.4

    3. XM_017597403.3 → XP_017452892.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X2

      UniProtKB/TrEMBL
      A6HJM3

    4. XM_006247380.5 → XP_006247442.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X4

      UniProtKB/TrEMBL
      A6HJM3, D4A6U1
      Related
      ENSRNOP00000076197.3, ENSRNOT00000093604.3
      Conserved Domains (6) summary
      smart00608
      Location:534 → 672
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:243 → 440
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:457 → 531
      Disintegrin; Disintegrin
      pfam01421
      Location:243 → 442
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:80 → 192
      Pep_M12B_propep; Reprolysin family propeptide
      pfam07974
      Location:681 → 713
      EGF_2; EGF-like domain

    5. XM_017597404.3 → XP_017452893.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X5

    6. XM_017597405.3 → XP_017452894.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X6

    7. XM_063269447.1 → XP_063125517.1  disintegrin and metalloproteinase domain-containing protein 11 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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