Entpd3 ectonucleoside triphosphate diphosphohydrolase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Entpd3provided by RGD
Official Full Name: ectonucleoside triphosphate diphosphohydrolase 3provided by RGD
Primary source: RGD:631326
See related: EnsemblRapid:ENSRNOG00000018982 AllianceGenome:RGD:631326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NTPDase3
Summary: Predicted to enable GDP phosphatase activity; UDP phosphatase activity; and ribonucleoside triphosphate phosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process. Predicted to act upstream of or within nucleoside triphosphate catabolic process. Predicted to be active in plasma membrane. Orthologous to human ENTPD3 (ectonucleoside triphosphate diphosphohydrolase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 33.9), Lung (RPKM 12.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (129124540..129155528)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (120246412..120277943)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (129201000..129232436)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prominent enhancement of NTPDase3-ir in the hypothalamus coincides with age when animals acquire diurnal rhythms of sleeping and feeding, supporting the hypothesis that this enzyme may be involved in regulation of homeostatic functions
Title: Expression of ecto-nucleoside triphosphate diphosphohydrolase3 (NTPDase3) in the female rat brain during postnatal development.
Cortical stab injury induces rapid varicose swelling on ectonucleoside triphosphate diphosphohydrolase 3-positive nerve fibers.
Title: The cortical stab injury induces beading of fibers expressing ecto-nucleoside triphosphate diphosphohydrolase 3.
we hypothesize that NTPDase-activity in neurons of the AN may play a permissive role in the regulation of the estrogen-induced pituitary LH-surge
Title: NTPDases in the neuroendocrine hypothalamus: possible energy regulators of the positive gonadotrophin feedback.
NTPDase3 has a role in the hypothalamus in the regulation of purinergic signaling and the tuning of energy supply for neurotransmission.
Title: Ecto-nucleoside triphosphate diphosphohydrolase 3 in the ventral and lateral hypothalamic area of female rats: morphological characterization and functional implications.
NTPDase3 ectodomain refolded from bacterial inclusion bodies was characterized.
Title: Characterization of Rat NTPDase1, -2, and -3 ectodomains refolded from bacterial inclusion bodies.
NTPDase3, by regulating the extracellular turnover of ATP, may modulate feeding, sleep-wake, and other behaviors through diverse homeostatic systems.
Title: Immunolocalization of ecto-nucleoside triphosphate diphosphohydrolase 3 in rat brain: implications for modulation of multiple homeostatic systems including feeding and sleep-wake behaviors.

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General gene information

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Markers

RH144532 (e-PCR)
- UniSTS:233777

RH134636 (e-PCR)
- UniSTS:217915

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables 5'-nucleotidase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables ribonucleoside triphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoside triphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in nucleoside diphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleoside diphosphate catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleoside triphosphate catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ectonucleoside triphosphate diphosphohydrolase 3

NP_835207.1

EC 3.6.1.5

XP_006244159.1

EC 3.6.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433860.1 → NP_001420789.1 ectonucleoside triphosphate diphosphohydrolase 3 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A0G2K5S7, A6I414, A6I415, Q80Z26
NM_001433861.1 → NP_001420790.1 ectonucleoside triphosphate diphosphohydrolase 3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A0G2K5S7
NM_178106.4 → NP_835207.1 ectonucleoside triphosphate diphosphohydrolase 3 isoform 1

See identical proteins and their annotated locations for NP_835207.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A0G2K5S7, A6I414, A6I415, Q80Z26

Related

ENSRNOP00000025663.3, ENSRNOT00000025663.7

Conserved Domains (1) summary

cl17037
Location:56 → 478

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

129124540..129155528

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244097.4 → XP_006244159.1 ectonucleoside triphosphate diphosphohydrolase 3 isoform X1

Related

ENSRNOP00000073543.2, ENSRNOT00000082377.3

Conserved Domains (1) summary

cl17037
Location:56 → 478

NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily