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    Esyt3 extended synaptotagmin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Esyt3provided by RGD
    Official Full Name
    extended synaptotagmin 3provided by RGD
    Primary source
    RGD:1561304
    See related
    EnsemblRapid:ENSRNOG00000022704 AllianceGenome:RGD:1561304
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam62c; RGD1561304
    Summary
    Predicted to enable calcium ion binding activity and phospholipid binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and lipid transport. Predicted to be located in cytoplasmic side of plasma membrane and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ESYT3 (extended synaptotagmin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 28.0), Testes (RPKM 15.0) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Esyt3 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (108749761..108796630, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (99870418..99917298, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (107555417..107602414, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene Fas apoptotic inhibitory molecule like Neighboring gene centrosomal protein 70 Neighboring gene DnaJ heat shock protein family (Hsp40) member C8, pseudogene 3 Neighboring gene uncharacterized LOC134480219 Neighboring gene muscle RAS oncogene homolog Neighboring gene NME/NM23 family member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains. Min SW, et al. Proc Natl Acad Sci U S A, 2007 Mar 6. PMID 17360437, Free PMC Article
    2. PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins. Giordano F, et al. Cell, 2013 Jun 20. PMID 23791178, Free PMC Article
    3. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Sandhu J, et al. Cell, 2018 Oct 4. PMID 30220461, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum-plasma membrane tethering IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    extended synaptotagmin-3
    Names
    extended synaptotagmin protein 3
    extended synaptotagmin-like protein 3
    family with sequence similarity 62 (C2 domain containing), member C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429430.1 → NP_001416359.1  extended synaptotagmin-3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I2D3, D3ZC04

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      108749761..108796630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266441.1 → XP_063122511.1  extended synaptotagmin-3 isoform X3

      UniProtKB/TrEMBL
      A6I2D3
      Related
      ENSRNOP00000108610.1, ENSRNOT00000142377.1

    2. XM_063266440.1 → XP_063122510.1  extended synaptotagmin-3 isoform X2

      UniProtKB/TrEMBL
      A6I2D3

    3. XM_343454.9 → XP_343455.4  extended synaptotagmin-3 isoform X1

      Related
      ENSRNOP00000017658.6, ENSRNOT00000017658.9
      Conserved Domains (4) summary
      cd04030
      Location:758 → 883
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:448 → 571
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:310 → 428
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:118 → 294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    4. XM_063266442.1 → XP_063122512.1  extended synaptotagmin-3 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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