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    Nek4 NIMA-related kinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nek4provided by RGD
    Official Full Name
    NIMA-related kinase 4provided by RGD
    Primary source
    RGD:1304995
    See related
    EnsemblRapid:ENSRNOG00000017997 AllianceGenome:RGD:1304995
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable manganese ion binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of DNA-templated transcription; protein phosphorylation; and regulation of cellular senescence. Located in ciliary plasm; ciliary transition zone; and cytoskeleton. Orthologous to human NEK4 (NIMA related kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 47.7), Adrenal (RPKM 46.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nek4 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6151292..6200280)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6144900..6185376)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (7035002..7080272)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene inter-alpha trypsin inhibitor, heavy chain 3 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 1 Neighboring gene signal peptidase complex subunit 1 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene small nucleolar RNA SNORD19B Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene G protein nucleolar 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Activity and substrate specificity of the murine STK2 Serine/Threonine kinase that is structurally related to the mitotic regulator protein NIMA of Aspergillus nidulans. Hayashi K, et al. Biochem Biophys Res Commun, 1999 Oct 22. PMID 10529384
    2. Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. Nguyen CL, et al. Mol Cell Biol, 2012 Oct. PMID 22851694, Free PMC Article
    3. The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase. Coene KL, et al. Hum Mol Genet, 2011 Sep 15. PMID 21685204
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary plasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary transition zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek4
    Names
    NIMA (never in mitosis gene a)-related expressed kinase 4
    NIMA (never in mitosis gene a)-related kinase 4
    NP_001013152.2
    XP_038950371.1
    XP_063131360.1
    XP_063131361.1
    XP_063131362.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013134.2 → NP_001013152.2  serine/threonine-protein kinase Nek4

      See identical proteins and their annotated locations for NP_001013152.2

      Status: PROVISIONAL

      Source sequence(s)
      CH474046
      UniProtKB/TrEMBL
      A0A8I6A574, A6KG16, D3ZDV9
      Related
      ENSRNOP00000024296.7, ENSRNOT00000024296.9
      Conserved Domains (2) summary
      smart00220
      Location:6 → 261
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08223
      Location:5 → 261
      STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      6151292..6200280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275290.1 → XP_063131360.1  serine/threonine-protein kinase Nek4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A574
      Related
      ENSRNOP00000078317.2, ENSRNOT00000095362.2

    2. XM_039094443.2 → XP_038950371.1  serine/threonine-protein kinase Nek4 isoform X2

      Conserved Domains (1) summary
      cd08223
      Location:5 → 261
      STKc_Nek4; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4

    3. XM_063275291.1 → XP_063131361.1  serine/threonine-protein kinase Nek4 isoform X3

    4. XM_063275292.1 → XP_063131362.1  serine/threonine-protein kinase Nek4 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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