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    Eif5b eukaryotic translation initiation factor 5B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308306, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eif5bprovided by RGD
    Official Full Name
    eukaryotic translation initiation factor 5Bprovided by RGD
    Primary source
    RGD:735017
    See related
    EnsemblRapid:ENSRNOG00000023356 AllianceGenome:RGD:735017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and nucleic acid binding activity. Predicted to be involved in regulation of translational initiation; ribosome assembly; and translational initiation. Predicted to be active in cytoplasm and synapse. Orthologous to human EIF5B (eukaryotic translation initiation factor 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 136.9), Spleen (RPKM 123.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Eif5b in Genome Data Viewer
    Location:
    9q21
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (47718706..47773289)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (40222769..40277482)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (44658724..44713518)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene lysozyme G1 Neighboring gene thioredoxin domain containing 9 Neighboring gene REV1, DNA directed polymerase Neighboring gene uncharacterized LOC134480569

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables membrane scission GTPase motor activity  
    enables metal ion binding  
    enables protein binding PubMed 
    enables tRNA binding  
    enables translation initiation factor activity  
    enables translation initiation factor activity  
    enables translation initiation factor activity  
    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in regulation of translational initiation  
    involved_in ribosome assembly  
    involved_in translational initiation  
    involved_in translational initiation  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    NOT located_in nucleus  
    is_active_in synapse  

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 5B
    Names
    annexin V-binding protein ABP-7
    eIF-5B
    translation initiation factor IF-2
    NP_001103611.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110141.1NP_001103611.1  eukaryotic translation initiation factor 5B

      See identical proteins and their annotated locations for NP_001103611.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      A0JN31, B2GUV7, P70488
      UniProtKB/TrEMBL
      A0A8I5ZM99
      Related
      ENSRNOP00000079088.1, ENSRNOT00000114110.2
      Conserved Domains (5) summary
      cd01887
      Location:628841
      IF2_eIF5B; Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family
      PRK04004
      Location:6231198
      PRK04004; translation initiation factor IF-2; Validated
      pfam11987
      Location:9621063
      IF-2; Translation-initiation factor 2
      cd03703
      Location:851961
      aeIF5B_II; Domain II of archaeal and eukaryotic Initiation Factor 5
      cd16266
      Location:10881182
      IF2_aeIF5B_IV; Domain IV of prokaryotic Initiation Factor 2 and archaeal and eukaryotic Initiation Factor 5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      47718706..47773289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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