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    Sesn2 sestrin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502988, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sesn2provided by RGD
    Official Full Name
    sestrin 2provided by RGD
    Primary source
    RGD:1566319
    See related
    EnsemblRapid:ENSRNOG00000042785 AllianceGenome:RGD:1566319
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566319
    Summary
    Predicted to enable several functions, including L-leucine binding activity; PH domain binding activity; and protein sequestering activity. Predicted to be involved in several processes, including cellular response to L-leucine; cellular response to leucine starvation; and regulation of TORC1 signaling. Predicted to act upstream of or within several processes, including positive regulation of lipophagy; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of protein kinase activity. Predicted to be located in cytoplasm. Predicted to be part of Atg1/ULK1 kinase complex; TORC2 complex; and nucleotide-activated protein kinase complex. Predicted to be active in lysosomal membrane. Orthologous to human SESN2 (sestrin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 154.9), Adrenal (RPKM 64.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Sesn2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149986304..150005255, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144702287..144721241, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150684891..150703846, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 18 Neighboring gene ribosomal protein S8, pseudogene 7 Neighboring gene uncharacterized LOC134487007 Neighboring gene ATP synthase inhibitory factor subunit 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C8 Neighboring gene microRNA 3583

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity  
    enables L-leucine binding  
    enables L-leucine binding  
    enables PH domain binding  
    enables oxidoreductase activity, acting on peroxide as acceptor  
    enables peroxidase activity  
    enables protein sequestering activity  
    NOT enables protein-containing complex binding  
    enables protein-containing complex binding  
    NOT enables sulfiredoxin activity  
    enables sulfiredoxin activity  
    Items 1 - 25 of 37
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-glucose import  
    involved_in DNA damage response, signal transduction by p53 class mediator  
    acts_upstream_of_or_within activation of protein kinase activity  
    NOT involved_in cellular oxidant detoxification  
    involved_in cellular oxidant detoxification  
    involved_in cellular response to L-leucine  
    involved_in cellular response to L-leucine  
    involved_in cellular response to amino acid starvation  
    involved_in cellular response to amino acid stimulus  
    involved_in cellular response to glucose starvation  
    involved_in cellular response to leucine starvation  
    involved_in cellular response to leucine starvation  
    involved_in cellular response to oxidative stress  
    acts_upstream_of_or_within fatty acid beta-oxidation  
    acts_upstream_of_or_within glucose homeostasis  
    acts_upstream_of_or_within mitochondrial DNA metabolic process  
    acts_upstream_of_or_within mitochondrion organization  
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of translation in response to endoplasmic reticulum stress  
    involved_in positive regulation of TORC1 signaling  
    acts_upstream_of_or_within positive regulation of lipophagy  
    involved_in positive regulation of macroautophagy  
    involved_in positive regulation of macroautophagy  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of protein localization to nucleus  
    involved_in reactive oxygen species metabolic process  
    involved_in regulation of TORC1 signaling  
    acts_upstream_of_or_within regulation of cAMP-dependent protein kinase activity  
    acts_upstream_of_or_within regulation of gluconeogenesis  
    acts_upstream_of_or_within regulation of protein phosphorylation  
    involved_in regulation of protein phosphorylation  
    involved_in regulation of response to reactive oxygen species  
    acts_upstream_of_or_within response to glucose  
    acts_upstream_of_or_within response to insulin  
    acts_upstream_of_or_within triglyceride homeostasis  
    Items 1 - 25 of 37
    Component Evidence Code Pubs
    part_of Atg1/ULK1 kinase complex  
    part_of TORC2 complex  
    located_in cytoplasm  
    is_active_in lysosomal membrane  
    located_in mitochondrion  
    part_of nucleotide-activated protein kinase complex  
    located_in nucleus  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109358.2NP_001102828.1  sestrin-2

      See identical proteins and their annotated locations for NP_001102828.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166423
      UniProtKB/TrEMBL
      A0A8I5Y865, A0A8J8YB21, B2GUV6, D3ZFT9
      Related
      ENSRNOP00000077718.1, ENSRNOT00000103737.2
      Conserved Domains (1) summary
      pfam04636
      Location:43479
      PA26; PA26 p53-induced protein (sestrin)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      149986304..150005255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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