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    Wnk3 WNK lysine deficient protein kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317420, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wnk3provided by RGD
    Official Full Name
    WNK lysine deficient protein kinase 3provided by RGD
    Primary source
    RGD:1563131
    See related
    EnsemblRapid:ENSRNOG00000002537 AllianceGenome:RGD:1563131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563131
    Summary
    Predicted to enable molecular condensate scaffold activity; potassium channel inhibitor activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of pancreatic juice secretion; regulation of metal ion transport; and regulation of protein localization to plasma membrane. Predicted to act upstream of or within maintenance of blood-brain barrier. Predicted to be located in adherens junction and bicellular tight junction. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Prieto syndrome. Orthologous to human WNK3 (WNK lysine deficient protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 113.1), Brain (RPKM 55.6) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Wnk3 in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (23599278..23742290)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (20156260..20299252)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (20316081..20459245)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene FYVE, RhoGEF and PH domain containing 1 Neighboring gene TSR2, ribosome maturation factor Neighboring gene ribosomal protein S12, pseudogene Neighboring gene U1 spliceosomal RNA Neighboring gene family with sequence similarity 120 member C Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables molecular condensate scaffold activity  
    enables potassium channel inhibitor activity  
    enables protein kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 26
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    acts_upstream_of cell volume homeostasis  
    acts_upstream_of_or_within cell volume homeostasis  
    involved_in cell volume homeostasis  
    involved_in cellular hyperosmotic response  
    involved_in chromatin remodeling  
    involved_in intracellular signal transduction  
    acts_upstream_of_or_within maintenance of blood-brain barrier  
    involved_in membraneless organelle assembly  
    involved_in monoatomic ion homeostasis  
    involved_in monoatomic ion homeostasis  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of pancreatic juice secretion  
    involved_in negative regulation of protein localization to plasma membrane  
    involved_in negative regulation of sodium ion transport  
    acts_upstream_of osmosensory signaling pathway  
    acts_upstream_of peptidyl-threonine phosphorylation  
    involved_in positive regulation of calcium ion transport  
    involved_in positive regulation of ion transmembrane transporter activity  
    involved_in positive regulation of peptidyl-threonine phosphorylation  
    involved_in positive regulation of potassium ion import across plasma membrane  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of sodium ion transmembrane transporter activity  
    involved_in positive regulation of sodium ion transport  
    involved_in protein autophosphorylation  
    involved_in protein localization to plasma membrane  
    involved_in regulation of calcium ion import  
    acts_upstream_of regulation of monoatomic cation transmembrane transport  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    located_in adherens junction  
    located_in bicellular tight junction  
    is_active_in cytoplasm  
    located_in cytoplasm  

    General protein information

    Preferred Names
    serine/threonine-protein kinase WNK3
    NP_001157079.1
    NP_001398747.1
    XP_006256845.1
    XP_008771338.1
    XP_008771339.1
    XP_008771340.1
    XP_017457560.1
    XP_038955733.1
    XP_038955734.1
    XP_063136128.1
    XP_063136129.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163607.1NP_001157079.1  serine/threonine-protein kinase WNK3 isoform 2

      See identical proteins and their annotated locations for NP_001157079.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474063
      UniProtKB/TrEMBL
      A6KLA2, D4A7Z8
      Related
      ENSRNOP00000042493.3, ENSRNOT00000047444.5
      Conserved Domains (3) summary
      smart00220
      Location:151404
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:135409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425462
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    2. NM_001411818.1NP_001398747.1  serine/threonine-protein kinase WNK3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A1W2Q671
      Related
      ENSRNOP00000076151.2, ENSRNOT00000093675.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      23599278..23742290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280058.1XP_063136128.1  serine/threonine-protein kinase WNK3 isoform X4

    2. XM_039099806.2XP_038955734.1  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q671
      Conserved Domains (2) summary
      cd14031
      Location:135409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425488
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    3. XM_008773116.4XP_008771338.1  serine/threonine-protein kinase WNK3 isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:151404
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:135409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425462
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    4. XM_017602071.3XP_017457560.1  serine/threonine-protein kinase WNK3 isoform X3

    5. XM_006256783.5XP_006256845.1  serine/threonine-protein kinase WNK3 isoform X1

      See identical proteins and their annotated locations for XP_006256845.1

      UniProtKB/TrEMBL
      A0A1W2Q671
      Conserved Domains (2) summary
      cd14031
      Location:135409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425488
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    6. XM_008773118.4XP_008771340.1  serine/threonine-protein kinase WNK3 isoform X5

      Conserved Domains (3) summary
      smart00220
      Location:151404
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:135409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425462
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    7. XM_063280059.1XP_063136129.1  serine/threonine-protein kinase WNK3 isoform X6

      UniProtKB/TrEMBL
      A0A0G2K2Y2
      Related
      ENSRNOP00000072423.2, ENSRNOT00000082177.3
    8. XM_008773117.4XP_008771339.1  serine/threonine-protein kinase WNK3 isoform X4

      Conserved Domains (3) summary
      smart00220
      Location:151404
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14031
      Location:135409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425462
      OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    9. XM_039099805.2XP_038955733.1  serine/threonine-protein kinase WNK3 isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q671
      Conserved Domains (2) summary
      cd14031
      Location:135409
      STKc_WNK3; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3
      pfam12202
      Location:425488
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
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