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    Rev3l REV3 like, DNA directed polymerase zeta catalytic subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309812, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rev3lprovided by RGD
    Official Full Name
    REV3 like, DNA directed polymerase zeta catalytic subunitprovided by RGD
    Primary source
    RGD:1307087
    See related
    EnsemblRapid:ENSRNOG00000000593 AllianceGenome:RGD:1307087
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-directed DNA polymerase activity. Predicted to be involved in double-strand break repair via homologous recombination and error-prone translesion synthesis. Predicted to act upstream of or within DNA repair. Predicted to be located in nucleolus. Predicted to be part of zeta DNA polymerase complex. Predicted to be active in nucleus. Orthologous to human REV3L (REV3 like, DNA directed polymerase zeta catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 176.1), Uterus (RPKM 135.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rev3l in Genome Data Viewer
    Location:
    20q12
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (44686482..44844668)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (43131841..43290102)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (44803664..44961362)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098872 Neighboring gene uncharacterized LOC134483824 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene peptidylprolyl isomerase G, pseudogene 2 Neighboring gene major facilitator superfamily domain containing 4B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Two percent of patients suspected of having Angelman syndrome have TCF4 mutations. Takano K, et al. Clin Genet, 2010 Sep. PMID 20184619
    2. Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage. Van Sloun PP, et al. Mol Cell Biol, 2002 Apr. PMID 11884603, Free PMC Article
    3. Crystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1. Hara K, et al. J Biol Chem, 2010 Apr 16. PMID 20164194, Free PMC Article
    4. Regulation of ubiquitin ligase dynamics by the nucleolus. Mekhail K, et al. J Cell Biol, 2005 Aug 29. PMID 16129783, Free PMC Article
    5. DNA polymerase δ and ζ switch by sharing accessory subunits of DNA polymerase δ. Baranovskiy AG, et al. J Biol Chem, 2012 May 18. PMID 22465957, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in error-prone translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of zeta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of zeta DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase zeta catalytic subunit
    Names
    REV3-like, catalytic subunit of DNA polymerase zeta
    REV3-like, polymerase (DNA directed), zeta, catalytic subunit
    NP_001077435.1
    XP_006256586.1
    XP_006256587.1
    XP_063135243.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083966.1 → NP_001077435.1  DNA polymerase zeta catalytic subunit

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6KIH1, F1M8G6
      Related
      ENSRNOP00000112650.1, ENSRNOT00000152978.1
      Conserved Domains (5) summary
      cd05778
      Location:2296 → 2534
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:2560 → 3008
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      pfam00136
      Location:2560 → 3007
      DNA_pol_B; DNA polymerase family B
      pfam14260
      Location:3044 → 3111
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:746 → 1132
      DUF4683; Domain of unknown function (DUF4683)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      44686482..44844668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279173.1 → XP_063135243.1  DNA polymerase zeta catalytic subunit isoform X3

      UniProtKB/TrEMBL
      A6KIH1
      Related
      ENSRNOP00000104523.1, ENSRNOT00000131491.1

    2. XM_006256524.3 → XP_006256586.1  DNA polymerase zeta catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A6KIH1
      Related
      ENSRNOP00000054053.3, ENSRNOT00000057227.5
      Conserved Domains (5) summary
      cd05778
      Location:2297 → 2535
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:2561 → 3009
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      pfam00136
      Location:2561 → 3008
      DNA_pol_B; DNA polymerase family B
      pfam14260
      Location:3045 → 3112
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:747 → 1133
      DUF4683; Domain of unknown function (DUF4683)

    3. XM_006256525.4 → XP_006256587.1  DNA polymerase zeta catalytic subunit isoform X2

      UniProtKB/TrEMBL
      A6KIH1
      Conserved Domains (5) summary
      cd05778
      Location:2219 → 2457
      DNA_polB_zeta_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
      cd05534
      Location:2483 → 2931
      POLBc_zeta; DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production ...
      pfam00136
      Location:2483 → 2930
      DNA_pol_B; DNA polymerase family B
      pfam14260
      Location:2967 → 3034
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
      pfam15735
      Location:669 → 1055
      DUF4683; Domain of unknown function (DUF4683)

    RNA

    1. XR_362259.3 RNA Sequence

    2. XR_005497269.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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